2024
The role of mitochondrial dynamics in oocyte and early embryo development
Yildirim R, Seli E. The role of mitochondrial dynamics in oocyte and early embryo development. Seminars In Cell And Developmental Biology 2024, 159: 52-61. PMID: 38330625, DOI: 10.1016/j.semcdb.2024.01.007.Peer-Reviewed Original ResearchMitochondrial dynamicsRegulating mitochondrial dynamicsImpaired mitochondrial dynamicsMorphology of mitochondriaMitochondria importDynamic organellesMitochondrial networkDysfunctional mitochondriaEmbryo developmentCellular processesPre-implantation embryo developmentPhospholipid synthesisMitochondriaHuman diseasesMitochondrial dysfunctionInnate immunityOlder reproductive age womenCell typesReproductive processesAffecting oocyte qualityCalcium regulationSuccess of pregnancyFemale reproductive healthReproductive age womenPost-fertilization
2022
Targeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve
Cozzolino M, Ergun Y, Seli E. Targeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve. Reproductive Sciences 2022, 30: 560-568. PMID: 35739352, DOI: 10.1007/s43032-022-01014-w.Peer-Reviewed Original ResearchConceptsMitofusin 1Mitofusin 2Double deletionFemale reproductive competencePotential functional redundancyDynamic organellesCellular homeostasisFunctional redundancyMitochondrial dynamicsEnvironmental stressMitochondrial functionMitochondrial dysfunctionMfn1Reproductive competenceTargeted deletionMfn2Oocyte maturationDeletionCritical roleReproductive agingFemale infertilityOocytesOocyte qualityFusion mechanismMitofusins
2019
Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve
Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott III R, Horvath T, Seli E. Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve. Cell Death & Disease 2019, 10: 560. PMID: 31332167, PMCID: PMC6646343, DOI: 10.1038/s41419-019-1799-3.Peer-Reviewed Original ResearchConceptsOocyte-granulosa cell communicationDynamic organellesAccumulation of ceramideFemale reproductive agingMitofusin 1Secondary follicle stageMitochondrial dynamicsCell communicationReproductive phenotypesCeramide synthesis inhibitor myriocinDevelopmental arrestApoptotic cell lossMitochondrial dysfunctionTargeted deletionOvarian follicular reserveOocyte maturationFemale fertilityFollicle stageDeletionPhenotypeReproductive agingOocytesCadherinFollicular reserveOrganelles