2019
Mitochondria as a Biomarker for IVF Outcome
Kim J, Seli E. Mitochondria as a Biomarker for IVF Outcome. Reproduction 2019, -1: r235-r242. PMID: 30844752, DOI: 10.1530/rep-18-0580.Peer-Reviewed Original ResearchConceptsKey cellular functionsAcid metabolismAmino acid metabolismCellular functionsMitochondrial DNASignal transductionFatty acid metabolismApoptotic regulationIon homeostasisEmbryo developmentMitochondrial contentInfertility treatment outcomesEmbryo metabolismAdvanced maternal ageMitochondriaEssential roleEmbryo viabilityIVF outcomesImplantation failureMaternal ageEuploid blastocystsTreatment outcomesAdditional biomarkersImplantation successMetabolism
2014
Metabolomic Assessment of Embryo Viability
Uyar A, Seli E. Metabolomic Assessment of Embryo Viability. Seminars In Reproductive Medicine 2014, 32: 141-152. PMID: 24515909, PMCID: PMC4109799, DOI: 10.1055/s-0033-1363556.Peer-Reviewed Original ResearchConceptsSingle embryo transferClinical pregnancyInitial promising resultsPreimplantation embryo metabolismPregnancy rateEmbryo selection processEmbryo viabilityEmbryo transferImplantation potentialSignificant associationConsistent benefitElimination of factorsConsecutive studiesClinical IVF laboratoryMetabolomic assessmentSuccess rateIVF laboratoryCulture mediumInconsistent findingsEmbryo metabolismMetabolomics studiesMetabolomics technologyDevelopmental potentialPrincipal studiesMedia metabolites
2008
Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics
Bromer JG, Seli E. Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Current Opinion In Obstetrics & Gynecology 2008, 20: 234-241. PMID: 18460937, DOI: 10.1097/gco.0b013e3282fe723d.Peer-Reviewed Original ResearchConceptsHigher multiple pregnancy rateEmbryo assessmentMultiple pregnancy rateReproductive technology cyclesLower implantation rateReproductive technologiesAssessment of glucoseCleavage rateImplantation rateUse of metabolomicsPregnancy rateRole of metabolomicsEmbryo culture mediumEmbryo viabilityUseful adjunctGood embryosAmino acid metabolismReproductive medicineMetabolomic profilingTechnology cyclesAcid metabolismOxygen consumptionOverview of studiesEmbryo metabolismProteomic profiling