2011
The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium
Karipcin FS, Ensari TA, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium. Reproductive Sciences 2011, 18: 145-155. PMID: 20889954, PMCID: PMC3343139, DOI: 10.1177/1933719110382307.Peer-Reviewed Original ResearchConceptsEctopic endometriumMenstrual cycleSecretory phaseCytokine expressionHuR expressionNormal endometriumCultured endometrial stromal cellsStromal cellsEctopic endometrial cellsEctopic human endometriumMid-menstrual phaseElevated cytokine levelsEndometrial stromal cellsLate secretory phasePathogenesis of endometriosisCultured stromal cellsTumor necrosis factorMessenger RNACytokine levelsEndometrial cellsEutopic endometriumHuman endometriumNecrosis factorEndometriumEndometriosis
2003
Pathogenesis of endometriosis
Seli E, Berkkanoglu M, Arici A. Pathogenesis of endometriosis. Obstetrics And Gynecology Clinics Of North America 2003, 30: 41-61. PMID: 12699257, DOI: 10.1016/s0889-8545(02)00052-9.Peer-Reviewed Original ResearchConceptsEndometrial tissueLocal aromatase activityViable endometrial tissueCases of endometriosisPathogenesis of endometriosisCommon gynecologic disorderRetrograde menstruation theoryRetrograde menstruationGynecologic disordersUterine cavityFallopian tubeEndometrial cellsPeritoneal surfaceAromatase activityPelvic organsPeritoneal cavityLow prevalenceTIMP expressionEndometriosisMenstruationTissueAdditional factorsPathogenesisPrevalenceDiseaseEndometriosis: Interaction of Immune and Endocrine Systems
Seli E, Arici A. Endometriosis: Interaction of Immune and Endocrine Systems. Seminars In Reproductive Medicine 2003, 21: 135-144. PMID: 12917783, DOI: 10.1055/s-2003-41320.Peer-Reviewed Original ResearchConceptsEndometriotic implantsRetrograde menstruationNatural killer cell activityGonadotropin-releasing hormone agonistKiller cell activityObserved clinical improvementCases of endometriosisHumoral immune responseDevelopment of endometriosisCommon gynecologic disorderEndometriosis implantsPelvic painClinical improvementGnRH agonistImmunologic alterationsHormone agonistEndometrial tissueGynecologic disordersHumoral immunityImmunomodulatory effectsUterine cavityImmune cellsMenstrual debrisPeritoneal fluidEndometrial cells
1998
Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells.
Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction 1998, 13: 3492-3495. PMID: 9886538, DOI: 10.1093/humrep/13.12.3492.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsFollicular fluidPeritoneal fluidEndometrial cellsCell proliferationStromal cellsEndometrial stromal cell culturesFollicular fluid contentEndometrial cell proliferationOocyte retrievalStromal cell culturesPeritoneal environmentCell proliferation assaysEndometriosisGrowth-promoting factorsGrowth-promoting effectProliferation assaysWomenMaximum cell proliferationProliferationCellsCell culturesHigher cell proliferationFluid content