2019
Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging
Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseTwo-cell embryo developmentUnfolded protein responseImpaired oocyte maturationMorphology of mitochondriaMitochondrial dysfunction resultsPremature reproductive agingNovel mechanistic insightsMitochondrial DNA contentReactive oxygen species productionPrevention of agingCLPP resultsProtein responseOxygen species productionReproductive agingPreimplantation embryosAge-related accumulationOxidative phosphorylationStress responseEmbryo developmentForm blastocystsMitochondrial functionMitochondriaMitochondrial dysfunctionEnergy metabolism
2014
Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications
Seli E, Babayev E, Collins SC, Nemeth G, Horvath TL. Minireview: Metabolism of Female Reproduction: Regulatory Mechanisms and Clinical Implications. Endocrinology 2014, 28: 790-804. PMID: 24678733, PMCID: PMC4042071, DOI: 10.1210/me.2013-1413.Peer-Reviewed Original ResearchConceptsFemale reproductionPeripheral availabilityMetabolic disturbancesMetabolic hormonesAnorexia nervosaClinical implicationsMetabolic determinantsHuman reproductionEnergy metabolismFemale fertilityMetabolic stateMetabolismCentral processesMellitusObesityHypothalamusRegulatory mechanismsInfertilityHormoneNervosa