2020
Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts
Yang M, Tao X, Titus S, Zhao T, Scott RT, Seli E. Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts. Molecular Human Reproduction 2020, 26: 702-711. PMID: 32663300, DOI: 10.1093/molehr/gaaa048.Peer-Reviewed Original ResearchConceptsInner cell massHuman preimplantation embryosEpigenetic regulationPreimplantation embryosCell lineage specificationChromatin accessibility landscapeAccessible chromatin landscapePreimplantation human blastocystsEarly embryonic developmentTranscription start siteCell massEarly embryo developmentHuman blastocystsDistal regionChromatin landscapeAccessible chromatinLineage specificationChromatin structureLow DNA inputATAC-seqTrophectoderm differentiationChromosome reorganizationAccessibility landscapeHuman embryonic materialEmbryonic development
2005
Spermatozoal nuclear determinants of reproductive outcome: implications for ART
Seli E, Sakkas D. Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Human Reproduction Update 2005, 11: 337-349. PMID: 15863434, DOI: 10.1093/humupd/dmi011.Peer-Reviewed Original ResearchConceptsPaternal genomeEpigenetic regulationChromosome contentDNA strand breaksNuclear determinantsStrand breaksGenomeImportant functionsNuclear factorRecent findingsSpecific mechanismsReproductive outcomesExact mechanismNumerical abnormalitiesAssisted reproduction technology (ART) outcomesTreatment addressesReproductionMale factor infertilityY chromosome microdeletionsMale fertility potentialRegulationOocytesMechanismChromosome microdeletionsFactor infertility