2013
Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary
Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary. Endocrinology 2013, 154: 3877-3887. PMID: 23913446, PMCID: PMC3776864, DOI: 10.1210/en.2013-1341.Peer-Reviewed Original ResearchConceptsGranulosa/cumulus cellsGranulosa cellsMouse ovariesReceptor expressionPrimary mouse granulosa cellsCumulus cellsPregnant mare serum gonadotropinIntracellular cAMPHormone receptor expressionGnRH receptor expressionCultured granulosa cellsOvarian granulosa cellsMouse granulosa cellsMechanism of actionGonadotoxic chemotherapyQuantitative RT-PCRGnRH agonistGnRHR mRNAFertility preservationMouse pituitary cellsLuciferase reporter plasmidSerum gonadotropinPituitary cell linePituitary cellsPituitary tissue
2011
Fertility preservation as a public health issue: an epidemiological perspective
Murk W, Seli E. Fertility preservation as a public health issue: an epidemiological perspective. Current Opinion In Obstetrics & Gynecology 2011, 23: 143-150. PMID: 21415745, DOI: 10.1097/gco.0b013e3283455270.Peer-Reviewed Original ResearchConceptsFertility preservation servicesSystemic lupus erythematosusFertility preservationCurrent epidemiological trendsAppropriate patient referralCancer survival ratesPublic health burdenSignificant psychosocial stressPublic health issuePreservation servicesLupus erythematosusPatient referralHealth burdenPatient educationEpidemiological trendsImpaired fertilityAverage ageReduced qualityPsychosocial stressSurvival rateHealthcare providersEpidemiological perspectivePatient accessHealth issuesLogistical barriers
2006
Stem cells and fertility: what does the future hold?
Kayisli UA, Seli E. Stem cells and fertility: what does the future hold? Current Opinion In Obstetrics & Gynecology 2006, 18: 338-343. PMID: 16735836, DOI: 10.1097/01.gco.0000193008.88652.23.Peer-Reviewed Original ResearchConceptsAdult miceStem cellsFetal ovarian developmentFertility preservationOocyte formationBone marrowClinical implicationsMammalian ovariesReproductive lifeInitial reportGenerations of oocytesScientific evidenceMiceRecent findingsOocytesNew oocytesCellsOvarian developmentProminent investigatorsTotal numberFindingsInvestigators
2005
Fertility preservation options for female patients with malignancies
Seli E, Tangir J. Fertility preservation options for female patients with malignancies. Current Opinion In Obstetrics & Gynecology 2005, 17: 299-308. PMID: 15870565, DOI: 10.1097/01.gco.0000169108.15623.34.Peer-Reviewed Original ResearchConceptsFemale patientsFertility preservationOocyte cryopreservationOvarian tissueGonadotropin-releasing hormone agonistRadical vaginal trachelectomyInitiation of chemotherapyFertility preservation optionsOvarian stimulation protocolsPreservation of fertilityCryopreserved ovarian tissueFirst embryo transferEmbryo cryopreservationImportant health issueVaginal trachelectomyConservative surgeryGynecologic malignanciesEndometrial cancerOvarian cryopreservationHormone agonistCervical cancerFirst pregnancyProgestin treatmentOvarian tumorsOrthotopic transplantation