2024
Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women
Esbert M, Tao X, Ballesteros A, Yildirim R, Scott R, Seli E. Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women. Molecular Human Reproduction 2024, 30: gaad048. PMID: 38180884, DOI: 10.1093/molehr/gaad048.Peer-Reviewed Original ResearchReproductive-age womenEuploidy rateCumulus cellsAutologous cumulus cellsAge womenReproductive ageRescue IVMOlder womenYoung donorsYoung reproductive age womenYoung womenOlder reproductive age womenOocyte maturationMetaphase II oocytesGerminal vesicle stage oocytesPolar bodyMaternal ageEuploid oocytesFirst polar bodyAddition of rapamycinHours of cultureII oocytesWomenCytogenetic constitutionRapamycin
2012
Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice
Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, Sasson I, Ilbay O, Sakkas D, Lowther KM, Mehlmann LM, Seli E. Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochemical Journal 2012, 446: 47-58. PMID: 22621333, PMCID: PMC3955213, DOI: 10.1042/bj20120467.Peer-Reviewed Original ResearchConceptsTranslational activationOocyte maturationZygotic genome activationFemale fertilityGenome activationGerminal vesicle stage oocytesDazl mRNAEarly embryogenesisMaternal mRNAsDownstream regulatorsMammalian reproductionGene expressionEPABStage oocytesXenopus oocytesEpidermal growthLate antral folliclesOogenesisMRNAOocytesMaturationProteinFemale miceCumulus expansionAntral follicles