2013
Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary
Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary. Endocrinology 2013, 154: 3877-3887. PMID: 23913446, PMCID: PMC3776864, DOI: 10.1210/en.2013-1341.Peer-Reviewed Original ResearchConceptsGranulosa/cumulus cellsGranulosa cellsMouse ovariesReceptor expressionPrimary mouse granulosa cellsCumulus cellsPregnant mare serum gonadotropinIntracellular cAMPHormone receptor expressionGnRH receptor expressionCultured granulosa cellsOvarian granulosa cellsMouse granulosa cellsMechanism of actionGonadotoxic chemotherapyQuantitative RT-PCRGnRH agonistGnRHR mRNAFertility preservationMouse pituitary cellsLuciferase reporter plasmidSerum gonadotropinPituitary cell linePituitary cellsPituitary tissue
2003
Endometriosis: Interaction of Immune and Endocrine Systems
Seli E, Arici A. Endometriosis: Interaction of Immune and Endocrine Systems. Seminars In Reproductive Medicine 2003, 21: 135-144. PMID: 12917783, DOI: 10.1055/s-2003-41320.Peer-Reviewed Original ResearchConceptsEndometriotic implantsRetrograde menstruationNatural killer cell activityGonadotropin-releasing hormone agonistKiller cell activityObserved clinical improvementCases of endometriosisHumoral immune responseDevelopment of endometriosisCommon gynecologic disorderEndometriosis implantsPelvic painClinical improvementGnRH agonistImmunologic alterationsHormone agonistEndometrial tissueGynecologic disordersHumoral immunityImmunomodulatory effectsUterine cavityImmune cellsMenstrual debrisPeritoneal fluidEndometrial cells