2020
Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization
Hanson BM, Tao X, Zhan Y, Kim JG, Klimczak AM, Herlihy NS, Scott RT, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization. Fertility And Sterility 2020, 115: 957-965. PMID: 33272640, DOI: 10.1016/j.fertnstert.2020.09.164.Peer-Reviewed Original ResearchConceptsWhite blood cellsPatient ageInfertile womenCumulus cellsBlood cellsEmbryonic aneuploidyPeak estradiol levelsAntimüllerian hormone levelsProspective cohort studyTelomere lengthNumber of oocytesShorter telomere lengthReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHigh rateWarrants further investigationTelomere length assessmentSignificant overlap existsCohort studyOocyte retrievalSingle centerEstradiol levelsInfertile populationMaternal agePolymerase chain reaction
2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescence
2006
Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
Daftary GS, Kayisli U, Seli E, Bukulmez O, Arici A, Taylor HS. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertility And Sterility 2006, 87: 367-372. PMID: 17173899, DOI: 10.1016/j.fertnstert.2006.06.041.Peer-Reviewed Original ResearchConceptsEndometrial HOXA10 expressionImplantation rateHOXA10 expressionInfertile womenFertile controlsHOXA10 mRNAPolymerase chain reaction findingsProspective clinical trialsReal-time reverse transcription-polymerase chain reactionReverse transcription-polymerase chain reactionHOXA10 protein expressionExpression of HOXA10Academic medical centerHOXA10 mRNA expressionGlandular epithelial cellsHomeobox gene HOXA10Potential molecular mechanismsBilateral hydrosalpinxHydrosalpinx fluidEndometrial stromaMidluteal phasePolymerase chain reactionClinical trialsSalpingectomyMedical Center
2005
Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window
Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Human Reproduction 2005, 20: 3012-3017. PMID: 16024536, DOI: 10.1093/humrep/dei188.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorInfertile womenLIF expressionFertile controlsExpression of LIFLeukemia inhibitory factor expressionAdverse effectsEndometrial LIF expressionPresence of hydrosalpingesWindow of implantationIVF-embryo transferGlandular epithelial cellsWestern blot findingsLIF immunoreactivityLIF levelsEndometrial receptivityEndometrial expressionImplantation windowPregnancy rateHydrosalpingesSalpingectomyImmunohistochemical analysisLow implantationInhibitory factorFactor expression