2018
Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications
Morin SJ, Seli E. Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications. Seminars In Reproductive Medicine 2018, 36: 195-203. PMID: 30866006, DOI: 10.1055/s-0038-1677048.Peer-Reviewed Original ResearchConceptsSevere male factor infertilityART-exposed childrenLow birth weightMale factor infertilityReproductive technologiesSevere monogenic disordersAssisted Reproductive TechnologyMultiple gestationsSubfertile womenFactor infertilityMetabolic derangementsPremature birthAbsolute riskBirth weightCardiovascular diseaseAdditional diagnosisNumber of womenClinical realityMultiple studiesMonogenic disordersNumber of couplesRiskOrigin of diseaseDiseaseWomen
2005
Spermatozoal nuclear determinants of reproductive outcome: implications for ART
Seli E, Sakkas D. Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Human Reproduction Update 2005, 11: 337-349. PMID: 15863434, DOI: 10.1093/humupd/dmi011.Peer-Reviewed Original ResearchConceptsPaternal genomeEpigenetic regulationChromosome contentDNA strand breaksNuclear determinantsStrand breaksGenomeImportant functionsNuclear factorRecent findingsSpecific mechanismsReproductive outcomesExact mechanismNumerical abnormalitiesAssisted reproduction technology (ART) outcomesTreatment addressesReproductionMale factor infertilityY chromosome microdeletionsMale fertility potentialRegulationOocytesMechanismChromosome microdeletionsFactor infertility