Mitochondria as determinants of reproductive senescence and competence: implications for diagnosis of embryo competence in assisted reproduction
Yildirim R, Seli E. Mitochondria as determinants of reproductive senescence and competence: implications for diagnosis of embryo competence in assisted reproduction. Human Reproduction 2024, 39: 2160-2170. PMID: 39066612, DOI: 10.1093/humrep/deae171.Peer-Reviewed Original ResearchMultiple quality control mechanismsMitochondrial unfolded protein responseMitochondrial DNA copy numberUnfolded protein responseQuality control mechanismsDNA copy numberMitochondrial networkRegulate calcium signalingMitochondrial dynamicsReproductive successMitochondrial quantityProtein responseDinucleotide contentModulate apoptosisOxidative phosphorylationCellular pathwaysCopy numberMitochondrial dysfunctionMitochondriaCalcium signalingEmbryo competenceMembrane potentialAssisted reproductionDiagnostic targetsReproductive senescenceThe role of mitochondrial dynamics in oocyte and early embryo development
Yildirim R, Seli E. The role of mitochondrial dynamics in oocyte and early embryo development. Seminars In Cell And Developmental Biology 2024, 159: 52-61. PMID: 38330625, DOI: 10.1016/j.semcdb.2024.01.007.Peer-Reviewed Original ResearchMitochondrial dynamicsRegulating mitochondrial dynamicsImpaired mitochondrial dynamicsMorphology of mitochondriaMitochondria importDynamic organellesMitochondrial networkDysfunctional mitochondriaEmbryo developmentCellular processesPre-implantation embryo developmentPhospholipid synthesisMitochondriaHuman diseasesMitochondrial dysfunctionInnate immunityOlder reproductive age womenCell typesReproductive processesAffecting oocyte qualityCalcium regulationSuccess of pregnancyFemale reproductive healthReproductive age womenPost-fertilization