2024
The role of mitochondrial dynamics in oocyte and early embryo development
Yildirim R, Seli E. The role of mitochondrial dynamics in oocyte and early embryo development. Seminars In Cell And Developmental Biology 2024, 159: 52-61. PMID: 38330625, DOI: 10.1016/j.semcdb.2024.01.007.Peer-Reviewed Original ResearchMitochondrial dynamicsRegulating mitochondrial dynamicsImpaired mitochondrial dynamicsMorphology of mitochondriaMitochondria importDynamic organellesMitochondrial networkDysfunctional mitochondriaEmbryo developmentCellular processesPre-implantation embryo developmentPhospholipid synthesisMitochondriaHuman diseasesMitochondrial dysfunctionInnate immunityOlder reproductive age womenCell typesReproductive processesAffecting oocyte qualityCalcium regulationSuccess of pregnancyFemale reproductive healthReproductive age womenPost-fertilization
2019
Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging
Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseTwo-cell embryo developmentUnfolded protein responseImpaired oocyte maturationMorphology of mitochondriaMitochondrial dysfunction resultsPremature reproductive agingNovel mechanistic insightsMitochondrial DNA contentReactive oxygen species productionPrevention of agingCLPP resultsProtein responseOxygen species productionReproductive agingPreimplantation embryosAge-related accumulationOxidative phosphorylationStress responseEmbryo developmentForm blastocystsMitochondrial functionMitochondriaMitochondrial dysfunctionEnergy metabolism