2005
The significance of sperm nuclear DNA strand breaks on reproductive outcome
Spano M, Seli E, Bizzaro D, Manicardi GC, Sakkas D. The significance of sperm nuclear DNA strand breaks on reproductive outcome. Current Opinion In Obstetrics & Gynecology 2005, 17: 255-260. PMID: 15870559, DOI: 10.1097/01.gco.0000169102.77504.66.Peer-Reviewed Original ResearchConceptsNuclear DNA strand breaksDNA strand breaksStrand breaksDNA abnormalitiesPaternal genomeChromatin structureNuclear DNASperm nuclear DNASperm nucleiSperm chromatin structureNuclear abnormalitiesReproductive parametersBlastocyst developmentSpermatozoaBody of evidenceNuclear anomaliesGenomeDNA anomaliesBreaksDNAReproductionSpermatogenesisAssisted reproduction technologyFertilizationReproductive outcomes
2004
The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail?
Sakkas D, Seli E, Manicardi GC, Nijs M, Ombelet W, Bizzaro D. The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail? Human Fertility 2004, 7: 99-103. PMID: 15223758, DOI: 10.1080/14647270410001720464.Peer-Reviewed Original ResearchConceptsIntracytoplasmic sperm injectionNuclear DNA strand breaksDNA strand breaksAbnormal semen parametersAbnormal spermatozoaInfertile couplesMale infertilitySperm injectionSemen parametersQuality of spermatozoaAssisted reproductionStrand breaksCertain causesHuman spermatozoaSuch spermApoptosisSuccessful useNumerous studiesSpermatozoaPatients
2003
Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis
Sakkas D, Seli E, Bizzaro D, Tarozzi N, Manicardi GC. Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reproductive BioMedicine Online 2003, 7: 428-432. PMID: 14656403, DOI: 10.1016/s1472-6483(10)61886-x.Peer-Reviewed Original ResearchConceptsNuclear DNA strand breaksDNA strand breaksAbnormal semen parametersAbnormal spermatozoaMale infertilitySemen parametersAbnormal persistenceApoptotic marker proteinsStrand breaksCertain causesHuman spermatozoaMarker proteinsApoptosisNumerous studiesSpermatogenesisSpermatozoaHumansInfertilityAbnormalities