2020
Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization
Hanson BM, Tao X, Zhan Y, Kim JG, Klimczak AM, Herlihy NS, Scott RT, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization. Fertility And Sterility 2020, 115: 957-965. PMID: 33272640, DOI: 10.1016/j.fertnstert.2020.09.164.Peer-Reviewed Original ResearchConceptsWhite blood cellsPatient ageInfertile womenCumulus cellsBlood cellsEmbryonic aneuploidyPeak estradiol levelsAntimüllerian hormone levelsProspective cohort studyTelomere lengthNumber of oocytesShorter telomere lengthReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHigh rateWarrants further investigationTelomere length assessmentSignificant overlap existsCohort studyOocyte retrievalSingle centerEstradiol levelsInfertile populationMaternal agePolymerase chain reaction
2015
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells
Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.Peer-Reviewed Original ResearchConceptsIVF-intracytoplasmic sperm injectionMiR-21-5p expressionPoor respondersMiR-21-5pMiR-21-3pCumulus cellsHuman granulosa-like tumor cellsMicro-ribonucleic acid (miRNA) expressionMiR-21-3p expressionLower serum E2 levelsMiR-21Elevated expressionPoor ovarian responseSerum E2 levelsReverse transcription real-time polymerase chain reactionTranscription real-time polymerase chain reactionNumber of oocytesLower E2 concentrationsAcademic medical centerReal-time polymerase chain reactionRespective age groupsMicroRNA microarray analysisOvarian responseAltered miRNA expressionE2 levels