2022
Distress response in granulosa cells of women affected by PCOS with or without insulin resistance
Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeHomeostasis model assessmentPCOS-IRInsulin resistanceHealthy oocyte donorsCumulus GCsOvarian syndromePCOS groupPlasma glucoseCONT groupMetabolic dysfunctionPathological changesFollicular microenvironmentConclusionOur findingsOocyte donorsGranulosa cellsModel assessmentQRT-PCRWomenER stressCONTMolecular mechanismsCell stressDistress responsesGroup
2020
Mitochondrial DNA content decreases during in vitro human embryo development: insights into mitochondrial DNA variation in preimplantation embryos donated for research
Pérez-Sánchez M, Díez-Juan A, Beltrán D, Mifsud A, Mercader A, Vidal C, Labarta E, Pellicer A, Seli E, De Los Santos MJ. Mitochondrial DNA content decreases during in vitro human embryo development: insights into mitochondrial DNA variation in preimplantation embryos donated for research. F&S Science 2020, 1: 36-45. PMID: 35559739, DOI: 10.1016/j.xfss.2020.05.001.Peer-Reviewed Original ResearchDay 3 embryosMetaphase II oocytesMtDNA contentII oocytesFailed-fertilized oocytesMtDNA copy numberProspective cohort studySignificant decreaseHuman metaphase II oocytesQuantitative polymerase chain reactionCohort studyFertilization patientsDNA loadPolymerase chain reactionPreimplantation embryo developmentAneuploid blastocystsOocyte donorsTotal mtDNA copy numberHuman oocytesEmbryo culture conditionsHuman embryo developmentCategorical variablesEmbryo developmentChain reaction
2010
Gay men choosing parenthood through assisted reproduction: medical and psychosocial considerations
Greenfeld DA, Seli E. Gay men choosing parenthood through assisted reproduction: medical and psychosocial considerations. Fertility And Sterility 2010, 95: 225-229. PMID: 20643400, DOI: 10.1016/j.fertnstert.2010.05.053.Peer-Reviewed Original ResearchThird party reproduction and the aging couple
Luk J, Greenfeld DA, Seli E. Third party reproduction and the aging couple. Maturitas 2010, 66: 389-396. PMID: 20451337, DOI: 10.1016/j.maturitas.2010.03.024.Peer-Reviewed Original ResearchConceptsThird-party reproductionOocyte donationFirst pregnancyInfertility treatmentSignificant success rateAverage ageOocyte donorsSocial workersMore womenCommon formSuccess rateReproductive technologiesLate 30sPregnancyEarly 40sPartner's advancesAgeFemale agePartiesUnited StatesPhysical involvementDonationUterusGratifying experienceNurses