2022
Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response
Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Human Reproduction 2022, 37: 1274-1286. PMID: 35451009, PMCID: PMC9156844, DOI: 10.1093/humrep/deac069.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsYoung poor respondersPolycystic ovary syndromePoor ovarian responseGCs of PCOSOvarian granulosa cellsBlood mononuclear cellsGranulosa cellsMature folliclesPoor respondersMononuclear cellsRNA expression profilesNormal responseAge groupsSTUDY FUNDING/COMPETINGHigher menopausal ageRotterdam diagnostic criteriaOvarian hyperstimulation syndromeInstituto de Salud Carlos IIIPARTICIPANTS/MATERIALSAntral follicular countROLE OF CHANCEOvarian follicular dynamicsSame study groupIngenuity Pathway Analysis
2013
Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary
Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary. Endocrinology 2013, 154: 3877-3887. PMID: 23913446, PMCID: PMC3776864, DOI: 10.1210/en.2013-1341.Peer-Reviewed Original ResearchConceptsGranulosa/cumulus cellsGranulosa cellsMouse ovariesReceptor expressionPrimary mouse granulosa cellsCumulus cellsPregnant mare serum gonadotropinIntracellular cAMPHormone receptor expressionGnRH receptor expressionCultured granulosa cellsOvarian granulosa cellsMouse granulosa cellsMechanism of actionGonadotoxic chemotherapyQuantitative RT-PCRGnRH agonistGnRHR mRNAFertility preservationMouse pituitary cellsLuciferase reporter plasmidSerum gonadotropinPituitary cell linePituitary cellsPituitary tissue