2022
Distress response in granulosa cells of women affected by PCOS with or without insulin resistance
Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeHomeostasis model assessmentPCOS-IRInsulin resistanceHealthy oocyte donorsCumulus GCsOvarian syndromePCOS groupPlasma glucoseCONT groupMetabolic dysfunctionPathological changesFollicular microenvironmentConclusionOur findingsOocyte donorsGranulosa cellsModel assessmentQRT-PCRWomenER stressCONTMolecular mechanismsCell stressDistress responsesGroup
2002
Should patients with polycystic ovarian syndrome be treated with metformin?
Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Human Reproduction 2002, 17: 2230-2236. PMID: 12202407, DOI: 10.1093/humrep/17.9.2230.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeTreatment of PCOSInsulin-lowering agentsOvarian syndromePathogenesis of PCOSType 2 diabetes mellitusPromising therapeutic profileEarly spontaneous miscarriageOral antihyperglycaemic agentsInsulin-sensitizing drugsType 2 diabetesRisk of developmentImportant aetiologic factorPlasminogen activator inhibitorSerum lipidsDiabetes mellitusCardioprotective effectsAetiologic factorsAntihyperglycaemic agentsInsulin resistanceSpontaneous miscarriageMetforminTherapeutic profileActivator inhibitorTreatment