2024
Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial
Herlihy N, Cakiroglu Y, Whitehead C, Reig A, Tiras B, Scott R, Seli E. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Human Reproduction 2024, 39: 1495-1503. PMID: 38725194, DOI: 10.1093/humrep/deae093.Peer-Reviewed Original ResearchPoor ovarian responseControlled ovarian stimulationHistory of poor ovarian responsePremature ovarian insufficiencyPlatelet-rich plasmaPlatelet-rich plasma injectionsMature oocyte yieldRandomized controlled trialsPRP injectionEuploid blastocystsOvarian responseOocyte yieldOocyte retrievalIVF outcomesIntraovarian platelet-rich plasmaUniversity-affiliated reproductive centerIVF historyMature oocytesSustained implantationDATE OF FIRST PATIENT’S ENROLMENT:Euploid embryo transferInclusion criteriaPlatelet-rich plasma preparationsPreimplantation genetic testingOvarian reserve tests
2022
Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
Cakiroglu Y, Yuceturk A, Karaosmanoglu O, Kopuk SY, Korun ZEU, Herlihy N, Scott RT, Tiras B, Seli E. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging 2022, 14: 2513-2523. PMID: 35320118, PMCID: PMC9004561, DOI: 10.18632/aging.203972.Peer-Reviewed Original ResearchConceptsPoor ovarian responseOvarian reserve parametersPlatelet-rich plasmaAutologous platelet-rich plasmaReserve parametersIntraovarian injectionIVF outcomesOvarian responsePRP treatmentProspective randomized clinical trialsRich plasmaHigher serum AMHLower serum FSHUnderwent embryo transferReproductive-age womenRandomized clinical trialsWide clinical applicationPOSEIDON criteriaSerum AMHSerum FSHPRP injectionClinical efficacyAge womenClinical trialsPregnancy rate
2020
Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency
Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, Tiras B, Seli E. Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency. Aging 2020, 12: 10211-10222. PMID: 32507764, PMCID: PMC7346073, DOI: 10.18632/aging.103403.Peer-Reviewed Original ResearchConceptsAutologous platelet-rich plasmaPrimary ovarian insufficiencyPlatelet-rich plasmaIVF outcome parametersAntral follicle countIntraovarian injectionOvarian reservePRP injectionAntimullerian hormoneOutcome parametersOvarian insufficiencyRich plasmaSerum antimullerian hormoneUnderwent embryo transferExperimental treatment optionsESHRE criteriaSustained implantationOvarian stimulationSerum follicleFollicle countPRP treatmentTreatment optionsFertilization outcomeAntral folliclesEmbryo transfer