2024
PATIENTS WITH POOR OVARIAN RESPONSE (POR) ARE LESS LIKELY TO SUCCEED IN ELECTIVE FERTILITY PRESERVATION AND REQUIRE TWICE AS MANY CYCLES TO DO SO, INDEPENDENT OF THE DEGREE OF POR
Vessa B, Reig A, Barrett F, Whitehead C, Seli E, Franasiak J. PATIENTS WITH POOR OVARIAN RESPONSE (POR) ARE LESS LIKELY TO SUCCEED IN ELECTIVE FERTILITY PRESERVATION AND REQUIRE TWICE AS MANY CYCLES TO DO SO, INDEPENDENT OF THE DEGREE OF POR. Fertility And Sterility 2024, 122: e246-e247. DOI: 10.1016/j.fertnstert.2024.07.778.Peer-Reviewed Original ResearchEffect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial
Herlihy N, Cakiroglu Y, Whitehead C, Reig A, Tiras B, Scott R, Seli E. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Human Reproduction 2024, 39: 1495-1503. PMID: 38725194, DOI: 10.1093/humrep/deae093.Peer-Reviewed Original ResearchPoor ovarian responseControlled ovarian stimulationHistory of poor ovarian responsePremature ovarian insufficiencyPlatelet-rich plasmaPlatelet-rich plasma injectionsMature oocyte yieldRandomized controlled trialsPRP injectionEuploid blastocystsOvarian responseOocyte yieldOocyte retrievalIVF outcomesIntraovarian platelet-rich plasmaUniversity-affiliated reproductive centerIVF historyMature oocytesSustained implantationDATE OF FIRST PATIENT’S ENROLMENT:Euploid embryo transferInclusion criteriaPlatelet-rich plasma preparationsPreimplantation genetic testingOvarian reserve testsPoor ovarian response classification systems in the clinical setting – time for an update?
Reig A, Seli E. Poor ovarian response classification systems in the clinical setting – time for an update? Current Opinion In Obstetrics & Gynecology 2024, 36: 192-199. PMID: 38597510, DOI: 10.1097/gco.0000000000000950.Peer-Reviewed Original ResearchConceptsPoor ovarian responseOvarian responsePoor ovarian response definitionDefinition of poor ovarian responseSuccess of assisted reproductive technologiesEra of personalized medicineOvarian reserve markersAssisted reproductive technologyBologna criteriaEuploid embryosReserve markersReproductive technologyClassification systemDiagnostic criteriaPersonalized medicineCounseling toolEffective predictor
2023
Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging
Garg A, Seli E. Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging. Fertility And Sterility 2023, 121: 26-33. PMID: 37979607, DOI: 10.1016/j.fertnstert.2023.11.011.Peer-Reviewed Original ResearchConceptsPoor ovarian responseLeukocyte telomere lengthOvarian reserveTelomere lengthAssisted Reproductive TechnologyOvarian responseFollicular somatic cellsMethylome changesDNA methylomePrevalence of infertilityDiminished ovarian reserveSomatic cellsCellular agingEpigenetic clocksDNA methylation ageReproductive potentialReproductive declineOvarian agingSurrogate biomarkerCommon causeMethylomeART outcomesChronologic ageEmbryo aneuploidyReproductive function
2022
The use of intraovarian injection of autologous platelet rich plasma (PRP) in patients with poor ovarian response and premature ovarian insufficiency
Herlihy NS, Seli E. The use of intraovarian injection of autologous platelet rich plasma (PRP) in patients with poor ovarian response and premature ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2022, 34: 133-137. PMID: 35645011, DOI: 10.1097/gco.0000000000000784.Peer-Reviewed Original ResearchConceptsPoor ovarian responsePlatelet-rich plasmaPrimary ovarian insufficiencyPoor prognosis patientsPrognosis patientsOvarian reserveIntraovarian injectionOvarian responseOvarian insufficiencyLive birthsRich plasmaEffect of PRPAutologous platelet-rich plasmaIntra-ovarian injectionPremature ovarian insufficiencyMultiple live birthsProspective trialCase seriesClinical trialsPatient's abilityNovel treatmentsPatientsEmbryo yieldInsufficiencyTreatmentTranscriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response
Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Human Reproduction 2022, 37: 1274-1286. PMID: 35451009, PMCID: PMC9156844, DOI: 10.1093/humrep/deac069.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsYoung poor respondersPolycystic ovary syndromePoor ovarian responseGCs of PCOSOvarian granulosa cellsBlood mononuclear cellsGranulosa cellsMature folliclesPoor respondersMononuclear cellsRNA expression profilesNormal responseAge groupsSTUDY FUNDING/COMPETINGHigher menopausal ageRotterdam diagnostic criteriaOvarian hyperstimulation syndromeInstituto de Salud Carlos IIIPARTICIPANTS/MATERIALSAntral follicular countROLE OF CHANCEOvarian follicular dynamicsSame study groupIngenuity Pathway AnalysisFollicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial
Díaz-García C, Herraiz S, Pamplona L, Subirá J, Soriano MJ, Simon C, Seli E, Pellicer A. Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial. Fertility And Sterility 2022, 117: 747-755. PMID: 35367015, DOI: 10.1016/j.fertnstert.2021.12.034.Peer-Reviewed Original ResearchConceptsPoor ovarian responseAntral follicle countOvarian reserve markersLive birth rateOvarian fragmentationFollicular activationFollicle countOvarian responseReserve markersHormone levelsPregnancy rateReproductive outcomesEmbryo transferTotal antral follicle countMII oocytesSerum antimüllerian hormoneAntimüllerian hormone levelsBirth rateMetaphase II oocytesEmbryology (ESHRE) criteriaHippo pathway inhibitionAntimüllerian hormoneSecondary outcomesFertilization cyclesIVF outcomesOvarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
Cakiroglu Y, Yuceturk A, Karaosmanoglu O, Kopuk SY, Korun ZEU, Herlihy N, Scott RT, Tiras B, Seli E. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging 2022, 14: 2513-2523. PMID: 35320118, PMCID: PMC9004561, DOI: 10.18632/aging.203972.Peer-Reviewed Original ResearchConceptsPoor ovarian responseOvarian reserve parametersPlatelet-rich plasmaAutologous platelet-rich plasmaReserve parametersIntraovarian injectionIVF outcomesOvarian responsePRP treatmentProspective randomized clinical trialsRich plasmaHigher serum AMHLower serum FSHUnderwent embryo transferReproductive-age womenRandomized clinical trialsWide clinical applicationPOSEIDON criteriaSerum AMHSerum FSHPRP injectionClinical efficacyAge womenClinical trialsPregnancy rate
2021
Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency
Reig A, Herraiz S, Pellicer A, Seli E. Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2021, 33: 241-248. PMID: 33896920, DOI: 10.1097/gco.0000000000000703.Peer-Reviewed Original ResearchConceptsPoor ovarian responsePrimary ovarian insufficiencyLive birthsOngoing pregnancyOvarian responseOvarian insufficiencyAutologous platelet-rich plasmaBone marrow transplantFemale reproductive agingPlatelet-rich plasmaIntraovarian injectionOvarian transplantationMarrow transplantReproductive agingFertility treatmentReproductive medicineWomenPregnancyBirthInsufficiencyPrevious reportsPreliminary studyMechanical disruptionAkt stimulationCutting-edge strategies
2020
Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model
Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT, Seli EU. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Human Reproduction 2020, 35: 2579-2588. PMID: 33049778, DOI: 10.1093/humrep/deaa206.Peer-Reviewed Original ResearchConceptsPoor ovarian responseWhite blood cellsPolycystic ovary syndromeOvarian responseOvarian stimulationChronologic ageWBC samplesEpigenetic age accelerationCumulus cellsAge accelerationYoung womenSTUDY FUNDING/COMPETINGBlood cellsProspective cohort studyGood responder groupCommon clinical challengePeripheral blood samplesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of agePatient's chronologic ageGeneral health consequencesCC samplesAge-related changesAge prediction model
2018
Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance
Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAneuploidyBlastomeresDatabases, FactualEmbryo Culture TechniquesEmbryo TransferFemaleFertility Agents, FemaleFertilization in VitroHumansInfertility, FemaleLive BirthOvarian ReserveOvaryOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeConceptsPoor oocyte qualityOvarian reserveLive birth rateDiminished ovarian reserveOocyte yieldOocyte qualityBlastulation rateAMH levelsPoor respondersPoor responseFollicular depletionBirth rateEmbryo transferAneuploidy rateLower live birth ratesYoung womenSTUDY FUNDING/COMPETINGGood prognosis patientsOvarian reserve parametersOvarian reserve testingYoung poor respondersPoor ovarian responseRetrospective cohort studyLower oocyte yieldInterquartile range
2015
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells
Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility And Sterility 2015, 103: 1469-1476.e3. PMID: 25910568, PMCID: PMC5648585, DOI: 10.1016/j.fertnstert.2015.02.035.Peer-Reviewed Original ResearchConceptsIVF-intracytoplasmic sperm injectionMiR-21-5p expressionPoor respondersMiR-21-5pMiR-21-3pCumulus cellsHuman granulosa-like tumor cellsMicro-ribonucleic acid (miRNA) expressionMiR-21-3p expressionLower serum E2 levelsMiR-21Elevated expressionPoor ovarian responseSerum E2 levelsReverse transcription real-time polymerase chain reactionTranscription real-time polymerase chain reactionNumber of oocytesLower E2 concentrationsAcademic medical centerReal-time polymerase chain reactionRespective age groupsMicroRNA microarray analysisOvarian responseAltered miRNA expressionE2 levels