2024
Non-invasive preimplantation genetic testing for aneuploidy: is the promise real?
Volovsky M, Scott R, Seli E. Non-invasive preimplantation genetic testing for aneuploidy: is the promise real? Human Reproduction 2024, 39: 1899-1908. PMID: 38970367, DOI: 10.1093/humrep/deae151.Peer-Reviewed Original ResearchNon-invasive PGT-APGT-APreimplantation genetic testingIntegration of next-generation sequencingGenetic testingGenetic testing platformsNon-invasive preimplantation genetic testingNext-generation sequencingRisk of pregnancy lossAneuploidy screening methodsEmbryo culture mediumAmplification failureSegmental aneuploidyPregnancy lossCulture mediumClinical reliabilityAneuploidyDiagnostic precisionClinical settingDiagnostic inaccuracyEmbryo viabilityClinical adoptionEmbryosScreening methodDNA
2020
A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy
Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertility And Sterility 2020, 115: 627-637. PMID: 32863013, DOI: 10.1016/j.fertnstert.2020.07.052.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingSustained implantationPredictive valueGenetic testingClinical outcomesTrophectoderm biopsyAge-matched control groupImpact of biopsyPGT-A resultsAntral follicle countRecurrent pregnancy lossBody mass indexDetectable adverse impactAneuploid resultsSecondary outcomesFertilization cyclesFollicle countPrimary outcomeMass indexUsable blastocystsBlastocyst transferFertility centerPregnancy lossClinical error ratesStudy groupDevelopmental potential of aneuploid human embryos cultured beyond implantation
Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications 2020, 11: 3987. PMID: 32778678, PMCID: PMC7418029, DOI: 10.1038/s41467-020-17764-7.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAntigens, CDCadherinsCell AdhesionCell Cycle CheckpointsCell LineageChromosome SegregationChromosomes, Human, Pair 16Chromosomes, Human, Pair 21Embryo ImplantationEmbryo, MammalianEmbryonic DevelopmentFemaleGenes, erbB-1Genetic TestingHumansMonosomyMosaicismPregnancyStem CellsTrisomyConceptsEarly pregnancy lossAneuploid human embryosPre-implantation genetic testingHuman embryosPost-implantation developmentTrisomy 16 embryosPregnancy lossCell cycle arrestGenetic testingTrisomy 15Major causeCases of mosaicismCycle arrestE-cadherinTrisomy 21 embryosProtein E-cadherinHigh rateCommon aneuploidiesStem cellsPremature differentiationAbnormal numberAneuploidyCell adhesion protein E-cadherinDevelopmental potentialArrest
2019
Diminished ovarian reserve versus ovarian aging: overlaps and differences.
Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences. Current Opinion In Obstetrics & Gynecology 2019, 31: 139-147. PMID: 30870184, DOI: 10.1097/gco.0000000000000536.Peer-Reviewed Original ResearchConceptsNormal ovarian reserveOvarian reservePregnancy lossOocyte qualityReproductive technology cyclesAge-matched womenDiminished ovarian reserveLow ovarian reserveFetal chromosomal abnormalitiesQuantitative declineFecundity of womenOvarian stimulationNatural conceptionOvarian agingPoor responseART treatmentAged womenYoung womenChromosomal abnormalitiesAvailable evidenceDecreased numberQualitative declineOocyte poolWomenBlastocyst development