2024
Reply. Recurrent implantation failure in patients undergoing euploid embryo transfers are unlikely to be caused by unmodifiable extra-embryonic factors
Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply. Recurrent implantation failure in patients undergoing euploid embryo transfers are unlikely to be caused by unmodifiable extra-embryonic factors. Human Reproduction 2024, 39: 2370-2370. PMID: 39173607, DOI: 10.1093/humrep/deae185.Peer-Reviewed Original ResearchReply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best
Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best. Human Reproduction 2024, 39: 1575-1576. PMID: 38741229, DOI: 10.1093/humrep/deae096.Peer-Reviewed Original ResearchDoes recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human Reproduction 2024, 39: 974-980. PMID: 38452358, DOI: 10.1093/humrep/deae040.Peer-Reviewed Original ResearchEuploid blastocyst transferLive birth rateCumulative live birth rateBlastocyst transferEmbryo transferEuploid blastocystsImplant failureBirth ratePreimplantation genetic testing cyclesMulti-center retrospective studyDay of embryo transferCongenital uterine anomaliesEuploid embryo transferComprehensive chromosome screeningEndometrial preparation protocolsNon-obstructive azoospermiaModified natural cyclePositive pregnancy testOvarian stimulation protocolsRecurrent implantation failureParental karyotype abnormalitiesChromosome copy numberEuploid transfersTrophectoderm biopsyUterine anomalies
2021
A review of the pathophysiology of recurrent implantation failure
Franasiak JM, Alecsandru D, Forman EJ, Gemmell LC, Goldberg JM, Llarena N, Margolis C, Laven J, Schoenmakers S, Seli E. A review of the pathophysiology of recurrent implantation failure. Fertility And Sterility 2021, 116: 1436-1448. PMID: 34674825, DOI: 10.1016/j.fertnstert.2021.09.014.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureImplantation failureMaternal immune systemReproductive tract microbiomeLack of implantationEndometrial synchronyHematologic factorsAnatomic factorsEndocrine milieuReceptive endometriumMaternal interfaceEmbryo transferImmune systemApparent treatmentCompetent blastocystClinical phenomenaHuman reproductionPotential causesImplantationFailureReviewCross talkEndometriumPatientsFactors
2020
Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers
Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility And Sterility 2020, 115: 45-53. PMID: 33077239, DOI: 10.1016/j.fertnstert.2020.07.002.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureEuploid single-embryo transferLive birth rateSingle embryo transferImplantation rateImplantation failureEmbryo transferCumulative live birth rateSustained implantation ratesRetrospective cohort studyKaplan-Meier curvesReproductive technology centerDifference of outcomeBirth rateCumulative implantation rateLogistic regression modelsPositive heartbeatClinical pregnancyCohort studyMiscarriage rateMean ageEuploid blastocystsNormal uterusMAIN OUTCOMEGestational carrier