2019
The association between assisted reproductive technologies and low birth weight.
Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Current Opinion In Obstetrics & Gynecology 2019, 31: 183-187. PMID: 30893135, DOI: 10.1097/gco.0000000000000535.Peer-Reviewed Original ResearchConceptsLow birth weightFresh embryo transferFrozen embryo transferBirth weightNumber of embryosEmbryo transferReproductive technologiesART-conceived pregnanciesComparable birth weightMain risk factorsEndometrial preparationPerinatal outcomesMultiple gestationsRisk factorsAssisted reproductionPrematurityNewbornsIncidenceRecent studiesPregnancyGestationWeight
2018
Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications
Morin SJ, Seli E. Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications. Seminars In Reproductive Medicine 2018, 36: 195-203. PMID: 30866006, DOI: 10.1055/s-0038-1677048.Peer-Reviewed Original ResearchConceptsSevere male factor infertilityART-exposed childrenLow birth weightMale factor infertilityReproductive technologiesSevere monogenic disordersAssisted Reproductive TechnologyMultiple gestationsSubfertile womenFactor infertilityMetabolic derangementsPremature birthAbsolute riskBirth weightCardiovascular diseaseAdditional diagnosisNumber of womenClinical realityMultiple studiesMonogenic disordersNumber of couplesRiskOrigin of diseaseDiseaseWomenThe role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights
Cecchino GN, Seli E, Alves da Motta E, García-Velasco J. The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive BioMedicine Online 2018, 36: 686-697. PMID: 29598846, DOI: 10.1016/j.rbmo.2018.02.007.Peer-Reviewed Original ResearchConceptsMetabolic stress modelsMitochondrial functionFemale fertilityFemale reproductive processesPoor outcomeReplacement therapyOvarian agingMitochondrial DNA contentInfertility treatmentTherapeutic attemptsOocyte qualityClinical implicationsEmbryo potentialOocyte maturationReproductive processesPrecursor cellsEarly embryo developmentReproductive technologiesDisease-causing mutationsMitochondrial capacityRole of mitochondriaMitochondrial impactCurrent insightsTrophectoderm cellsWomen
2014
The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders
Uyar A, Seli E. The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders. Current Opinion In Obstetrics & Gynecology 2014, 26: 210-221. PMID: 24752003, PMCID: PMC4123998, DOI: 10.1097/gco.0000000000000071.Peer-Reviewed Original ResearchConceptsRelevant clinical dataReproductive technology proceduresConclusive clinical trialsBeckwith-Wiedemann syndromeCase seriesLarge registriesClinical trialsART proceduresClinical dataHigh prevalenceGeneral populationLow prevalenceART usePotential associationGenomic imprintingGene expressionDisordersEarly embryo developmentReproductive technologiesAllele-specific gene expressionFurther studiesTechnology proceduresPrevalenceImprinted gene expressionImprinting disorders
2011
Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis
Bromer JG, Ata B, Seli M, Lockwood CJ, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Current Opinion In Obstetrics & Gynecology 2011, 23: 168-173. PMID: 21372712, DOI: 10.1097/gco.0b013e32834551cd.Peer-Reviewed Original ResearchConceptsMultiple pregnanciesPreterm deliveryPreterm infantsNumber of embryosInfant deliveryAssisted reproductive technology cyclesElective single embryo transferART live birthsReproductive technology cyclesSingle embryo transferFinancial burdenART neonatesART twinsMedical complicationsART cyclesLive birthsSubstantial burdenMean costPregnancyEmbryo transferART tripletsInfantsHealthcare expendituresHealth science policyReproductive technologies
2010
Economics of assisted reproductive technologies
Ata B, Seli E. Economics of assisted reproductive technologies. Current Opinion In Obstetrics & Gynecology 2010, 22: 183-188. PMID: 20125015, DOI: 10.1097/gco.0b013e3283373c13.Peer-Reviewed Original ResearchConceptsART utilization ratesNumber of embryosMultiple pregnanciesPocket expensesPrematurity-related complicationsAchievement of pregnancySingle embryo transferCost of ARTReproductive technologiesReimbursement plansNational healthcare expendituresTreatment attemptsART utilizationEconomic burdenEmbryo transferPregnancyHealthcare expendituresReimbursement policiesPublic reimbursementDownstream costsIndustrialized worldUtilization rateComplicationsPatientsPhysiciansThird party reproduction and the aging couple
Luk J, Greenfeld DA, Seli E. Third party reproduction and the aging couple. Maturitas 2010, 66: 389-396. PMID: 20451337, DOI: 10.1016/j.maturitas.2010.03.024.Peer-Reviewed Original ResearchConceptsThird-party reproductionOocyte donationFirst pregnancyInfertility treatmentSignificant success rateAverage ageOocyte donorsSocial workersMore womenCommon formSuccess rateReproductive technologiesLate 30sPregnancyEarly 40sPartner's advancesAgeFemale agePartiesUnited StatesPhysical involvementDonationUterusGratifying experienceNurses
2008
Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics
Bromer JG, Seli E. Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Current Opinion In Obstetrics & Gynecology 2008, 20: 234-241. PMID: 18460937, DOI: 10.1097/gco.0b013e3282fe723d.Peer-Reviewed Original ResearchConceptsHigher multiple pregnancy rateEmbryo assessmentMultiple pregnancy rateReproductive technology cyclesLower implantation rateReproductive technologiesAssessment of glucoseCleavage rateImplantation rateUse of metabolomicsPregnancy rateRole of metabolomicsEmbryo culture mediumEmbryo viabilityUseful adjunctGood embryosAmino acid metabolismReproductive medicineMetabolomic profilingTechnology cyclesAcid metabolismOxygen consumptionOverview of studiesEmbryo metabolismProteomic profiling