The mRNA‐Binding Protein Zfp36 Is Upregulated by β‐Adrenergic Stimulation and Represses IL‐6 Production in 3T3‐L1 Adipocytes
Brahma PK, Zhang H, Murray BS, Shu F, Sidell N, Seli E, Kallen CB. The mRNA‐Binding Protein Zfp36 Is Upregulated by β‐Adrenergic Stimulation and Represses IL‐6 Production in 3T3‐L1 Adipocytes. Obesity 2012, 20: 40-47. PMID: 21818148, PMCID: PMC4127993, DOI: 10.1038/oby.2011.259.Peer-Reviewed Original ResearchConceptsAU-rich elementsZFP36 expressionCell type-specific modulatorsPost-transcriptional levelMRNA-binding proteinRetinoic acidZinc finger protein 36Novel mechanistic approachTarget mRNAsMRNA targetsSuch proteinsPotent repressorAdipocyte-derived IL-6Protein 36Chronic inflammatory stateSystemic immune responsesDevelopment of diabetesDependent pathwayDiverse inflammatory disordersZFP36IL-6 productionAdrenergic receptor agonist isoproterenolCyclic adenosine monophosphateInterleukin-6 expressionΒ-Adrenergic Stimulation