2024
Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review
Rodríguez-Eguren A, Bueno-Fernandez C, Gómez-Álvarez M, Francés-Herrero E, Pellicer A, Bellver J, Seli E, Cervelló I. Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review. Human Reproduction Update 2024, 30: 584-613. PMID: 38796750, PMCID: PMC11369227, DOI: 10.1093/humupd/dmae013.Peer-Reviewed Original ResearchPlatelet-rich plasmaAsherman's syndromeEndometrial atrophyIntrauterine adhesionsThin endometriumRegenerative therapyMesenchymal stem cellsEndometrial pathologyStem cellsPreclinical modelsEndometrial disordersClinical studiesRisk of poor pregnancy outcomesGrowth factorTreated with surgeryStem cell-based treatmentsPoor pregnancy outcomesTissue repairMaintenance of pregnancyPersonalized treatment regimensImprove reproductive outcomesCell-based treatmentsSystematic reviewHuman bone marrowEndometrial proliferation
2020
Developmental potential of aneuploid human embryos cultured beyond implantation
Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications 2020, 11: 3987. PMID: 32778678, PMCID: PMC7418029, DOI: 10.1038/s41467-020-17764-7.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAntigens, CDCadherinsCell AdhesionCell Cycle CheckpointsCell LineageChromosome SegregationChromosomes, Human, Pair 16Chromosomes, Human, Pair 21Embryo ImplantationEmbryo, MammalianEmbryonic DevelopmentFemaleGenes, erbB-1Genetic TestingHumansMonosomyMosaicismPregnancyStem CellsTrisomyConceptsEarly pregnancy lossAneuploid human embryosPre-implantation genetic testingHuman embryosPost-implantation developmentTrisomy 16 embryosPregnancy lossCell cycle arrestGenetic testingTrisomy 15Major causeCases of mosaicismCycle arrestE-cadherinTrisomy 21 embryosProtein E-cadherinHigh rateCommon aneuploidiesStem cellsPremature differentiationAbnormal numberAneuploidyCell adhesion protein E-cadherinDevelopmental potentialArrest
2015
Oocyte mitochondrial function and reproduction
Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Current Opinion In Obstetrics & Gynecology 2015, 27: 175-181. PMID: 25719756, PMCID: PMC4590773, DOI: 10.1097/gco.0000000000000164.Peer-Reviewed Original ResearchConceptsOocyte mitochondrial functionMitochondrial functionEmbryonic developmentMitochondrial nutrientsMitochondrial replacementRole of mitochondriaOogonial stem cellsCellular organellesMammalian reproductionMitochondrial performanceMitochondrial diseaseEmbryo developmentMitochondrial activityMitochondrial dysfunctionOocyte developmentMitochondriaReproductive consequencesStem cellsOocyte maturationMitochondrial abnormalitiesPolar bodyReproductionEnergy productionIntake of compoundsNegative long-term health effects
2006
Stem cells and fertility: what does the future hold?
Kayisli UA, Seli E. Stem cells and fertility: what does the future hold? Current Opinion In Obstetrics & Gynecology 2006, 18: 338-343. PMID: 16735836, DOI: 10.1097/01.gco.0000193008.88652.23.Peer-Reviewed Original ResearchConceptsAdult miceStem cellsFetal ovarian developmentFertility preservationOocyte formationBone marrowClinical implicationsMammalian ovariesReproductive lifeInitial reportGenerations of oocytesScientific evidenceMiceRecent findingsOocytesNew oocytesCellsOvarian developmentProminent investigatorsTotal numberFindingsInvestigators