2004
Treatment of PCOS with metformin and other insulin-sensitizing agents
Seli E, Duleba AJ. Treatment of PCOS with metformin and other insulin-sensitizing agents. Current Diabetes Reports 2004, 4: 69-75. PMID: 14764283, DOI: 10.1007/s11892-004-0014-8.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeInsulin-sensitizing agentsSerum insulinInsulin resistanceTreatment of PCOSType 2 diabetes mellitusElevated serum insulinUse of metforminTreatment of womenOvary syndromeCompensatory hyperinsulinemiaDiabetes mellitusOvulatory functionD-chiro-inositolAndrogen levelsCardiovascular disordersMetforminHyperinsulinemiaWomenSignificant proportionTreatmentInsulinAgentsHyperandrogenismAnovulation
2002
Should patients with polycystic ovarian syndrome be treated with metformin?
Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Human Reproduction 2002, 17: 2230-2236. PMID: 12202407, DOI: 10.1093/humrep/17.9.2230.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeTreatment of PCOSInsulin-lowering agentsOvarian syndromePathogenesis of PCOSType 2 diabetes mellitusPromising therapeutic profileEarly spontaneous miscarriageOral antihyperglycaemic agentsInsulin-sensitizing drugsType 2 diabetesRisk of developmentImportant aetiologic factorPlasminogen activator inhibitorSerum lipidsDiabetes mellitusCardioprotective effectsAetiologic factorsAntihyperglycaemic agentsInsulin resistanceSpontaneous miscarriageMetforminTherapeutic profileActivator inhibitorTreatmentOptimizing ovulation induction in women with polycystic ovary syndrome
Seli E, Duleba AJ. Optimizing ovulation induction in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2002, 14: 245-254. PMID: 12032379, DOI: 10.1097/00001703-200206000-00002.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeInsulin resistanceOvulation inductionSerum insulinOvulatory functionType 2 diabetes mellitusElevated serum insulinLaparoscopic ovarian drillingPartial ovarian resectionSignificant insulin resistanceCardiovascular risk factorsInsulin-sensitizing agentsNew therapeutic approachesOvarian drillingOvarian resectionClomiphene citrateMetformin useCompensatory hyperinsulinemiaDiabetes mellitusInsulin sensitivityRisk factorsAndrogen levelsTherapeutic approachesTraditional therapies