2013
Human embryonic poly(A)-binding protein (EPAB) alternative splicing is differentially regulated in human oocytes and embryos
Guzeloglu-Kayisli O, Lalioti MD, Babayev E, Torrealday S, Karakaya C, Seli E. Human embryonic poly(A)-binding protein (EPAB) alternative splicing is differentially regulated in human oocytes and embryos. Molecular Human Reproduction 2013, 20: 59-65. PMID: 24002949, DOI: 10.1093/molehr/gat061.Peer-Reviewed Original ResearchConceptsZygotic genome activationEarly embryo developmentEarly embryosTranslational activationSomatic tissuesSpliced formsEmbryo developmentEmbryo-specific expressionPost-transcriptional mechanismsOocyte maturationHuman somatic tissuesFull-length formGenome activationExon 8Transcriptional regulationAlternative splicingTranscriptional activityGene expressionHuman oocytesEPABAmino acidsXenopusEmbryosMRNAOocytes
2008
Identification and characterization of human embryonic poly(A) binding protein (EPAB)
Guzeloglu-Kayisli O, Pauli S, Demir H, Lalioti MD, Sakkas D, Seli E. Identification and characterization of human embryonic poly(A) binding protein (EPAB). Molecular Human Reproduction 2008, 14: 581-588. PMID: 18716053, DOI: 10.1093/molehr/gan047.Peer-Reviewed Original ResearchConceptsZygotic genome activationBinding proteinGene expressionInitial mitotic divisionsAmino acid proteinTranslational regulatory pathwaysEarly embryo developmentGenome activationModel organismsTranscriptional silencingMaternal mRNAsEarly embryosTranslational activationCytoplasmic polyadenylationSomatic tissuesAcid proteinRegulatory pathwaysMitotic divisionEmbryo developmentEPABProteinMRNA activationXenopusEmbryosCentral role