2022
Distress response in granulosa cells of women affected by PCOS with or without insulin resistance
Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGranulosa CellsHumansInsulin ResistancePolycystic Ovary SyndromeProtein Serine-Threonine KinasesTumor MicroenvironmentConceptsPolycystic ovarian syndromeHomeostasis model assessmentPCOS-IRInsulin resistanceHealthy oocyte donorsCumulus GCsOvarian syndromePCOS groupPlasma glucoseCONT groupMetabolic dysfunctionPathological changesFollicular microenvironmentConclusionOur findingsOocyte donorsGranulosa cellsModel assessmentQRT-PCRWomenER stressCONTMolecular mechanismsCell stressDistress responsesGroupTranscriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response
Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Human Reproduction 2022, 37: 1274-1286. PMID: 35451009, PMCID: PMC9156844, DOI: 10.1093/humrep/deac069.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGranulosa CellsHumansLeukocytes, MononuclearPolycystic Ovary SyndromeRNASirtuinsTranscriptomeConceptsPeripheral blood mononuclear cellsYoung poor respondersPolycystic ovary syndromePoor ovarian responseGCs of PCOSOvarian granulosa cellsBlood mononuclear cellsGranulosa cellsMature folliclesPoor respondersMononuclear cellsRNA expression profilesNormal responseAge groupsSTUDY FUNDING/COMPETINGHigher menopausal ageRotterdam diagnostic criteriaOvarian hyperstimulation syndromeInstituto de Salud Carlos IIIPARTICIPANTS/MATERIALSAntral follicular countROLE OF CHANCEOvarian follicular dynamicsSame study groupIngenuity Pathway Analysis
2020
Mitochondrial function in women with polycystic ovary syndrome.
Cozzolino M, Seli E. Mitochondrial function in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2020, 32: 205-212. PMID: 32068544, DOI: 10.1097/gco.0000000000000619.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLower mtDNA copy numberOvary syndromePathogenesis of PCOSMitochondrial dysfunctionMtDNA copy numberPotential protective rolePCOS phenotypeInsulin resistancePathophysiological mechanismsCommon findingDiagnostic modalitiesMetabolic milieuFunctional alterationsMitochondrial functional alterationsProtective roleCommon diseaseOxidative stressWomenMitochondrial functionDysfunctionSyndromeCopy numberProtein responseReactive oxygen
2004
Treatment of PCOS with metformin and other insulin-sensitizing agents
Seli E, Duleba AJ. Treatment of PCOS with metformin and other insulin-sensitizing agents. Current Diabetes Reports 2004, 4: 69-75. PMID: 14764283, DOI: 10.1007/s11892-004-0014-8.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansHypoglycemic AgentsInositol PhosphatesMetforminPolycystic Ovary SyndromePolysaccharidesThiazolidinedionesConceptsPolycystic ovary syndromeInsulin-sensitizing agentsSerum insulinInsulin resistanceTreatment of PCOSType 2 diabetes mellitusElevated serum insulinUse of metforminTreatment of womenOvary syndromeCompensatory hyperinsulinemiaDiabetes mellitusOvulatory functionD-chiro-inositolAndrogen levelsCardiovascular disordersMetforminHyperinsulinemiaWomenSignificant proportionTreatmentInsulinAgentsHyperandrogenismAnovulation
2002
Should patients with polycystic ovarian syndrome be treated with metformin?
Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Human Reproduction 2002, 17: 2230-2236. PMID: 12202407, DOI: 10.1093/humrep/17.9.2230.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousCardiovascular DiseasesDiabetes MellitusFemaleHumansHypoglycemic AgentsMenstrual CycleMetforminOvulation InductionPolycystic Ovary SyndromeRisk FactorsConceptsPolycystic ovarian syndromeTreatment of PCOSInsulin-lowering agentsOvarian syndromePathogenesis of PCOSType 2 diabetes mellitusPromising therapeutic profileEarly spontaneous miscarriageOral antihyperglycaemic agentsInsulin-sensitizing drugsType 2 diabetesRisk of developmentImportant aetiologic factorPlasminogen activator inhibitorSerum lipidsDiabetes mellitusCardioprotective effectsAetiologic factorsAntihyperglycaemic agentsInsulin resistanceSpontaneous miscarriageMetforminTherapeutic profileActivator inhibitorTreatmentOptimizing ovulation induction in women with polycystic ovary syndrome
Seli E, Duleba AJ. Optimizing ovulation induction in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2002, 14: 245-254. PMID: 12032379, DOI: 10.1097/00001703-200206000-00002.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicClomipheneFemaleFertility Agents, FemaleHumansMetforminOvulation InductionPolycystic Ovary SyndromePregnancyConceptsPolycystic ovary syndromeOvary syndromeInsulin resistanceOvulation inductionSerum insulinOvulatory functionType 2 diabetes mellitusElevated serum insulinLaparoscopic ovarian drillingPartial ovarian resectionSignificant insulin resistanceCardiovascular risk factorsInsulin-sensitizing agentsNew therapeutic approachesOvarian drillingOvarian resectionClomiphene citrateMetformin useCompensatory hyperinsulinemiaDiabetes mellitusInsulin sensitivityRisk factorsAndrogen levelsTherapeutic approachesTraditional therapies