2014
Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH
Karakaya C, Guzeloglu-Kayisli O, Hobbs RJ, Gerasimova T, Uyar A, Erdem M, Oktem M, Erdem A, Gumuslu S, Ercan D, Sakkas D, Comizzoli P, Seli E, Lalioti MD. Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH. Molecular Human Reproduction 2014, 20: 630-643. PMID: 24670307, PMCID: PMC4072182, DOI: 10.1093/molehr/gau024.Peer-Reviewed Original ResearchConceptsAlternative splicingAlternative skippingExon 2Species-specific regulationDNA sequence variationPost-transcriptional modificationsFull-length proteinNorth American originMammalian ovarian functionAmino acid substitutionsDifferent genetic backgroundsHormone receptor geneGood comparative modelResult of evolutionSequence variationFollicle-stimulating hormoneSplicing variantsSplicingSpecies-specific formsAcid substitutionsHEK293 cellsFollicle-stimulating hormone receptor (FSHR) geneGenetic backgroundHuman FSHRAmerican origin
2010
Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH
Gerasimova T, Thanasoula MN, Zattas D, Seli E, Sakkas D, Lalioti MD. Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 529-536. PMID: 20061434, PMCID: PMC2840851, DOI: 10.1210/jc.2009-1304.Peer-Reviewed Original ResearchConceptsOvarian responseFSH receptorFSHR mRNAAbnormal ovarian responseOvarian stimulation protocolsForms of infertilityOocytes of womenExtracellular ligand-binding portionHormone receptor variantsOvarian hyperstimulationOvarian stimulationFSHR variantsPoor responseInfertility treatmentT cellsStimulation protocolFollicle growthFSHFertility clinicsCAMP activationCumulus cellsReceptor variantsGenetic causeRT-PCRWomen