2019
Cumulus cells have longer telomeres than leukocytes in reproductive-age women
Lara-Molina EE, Franasiak JM, Marin D, Tao X, Díaz-Gimeno P, Florensa M, Martin M, Seli E, Pellicer A. Cumulus cells have longer telomeres than leukocytes in reproductive-age women. Fertility And Sterility 2019, 113: 217-223. PMID: 31594634, DOI: 10.1016/j.fertnstert.2019.08.089.Peer-Reviewed Original ResearchConceptsLeukocyte telomere lengthGranulosa cellsCumulus cellsTelomere lengthAssisted reproductive technology centerRelative leukocyte telomere lengthProspective noninterventional studyAntimüllerian hormone levelsAntral follicle countReproductive-age womenReproductive technology centerLonger telomeresNoninterventional studyFollicle countMean ageHormone levelsFollicular environmentMAIN OUTCOMEMature folliclesStudy subjectsSignificant associationFollicular cellsMean numberMature oocytesSignificant differences
2016
Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity
Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E. Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas 2016, 93: 121-130. PMID: 27523387, PMCID: PMC5064871, DOI: 10.1016/j.maturitas.2016.06.015.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesUnfolded protein response genesProtein response genesMitochondrial DNAMitochondrial dynamicsMitochondrial stressResponse genesMammalian reproductionMitochondria morphologyStressful conditionsMitochondrial changesMitochondriaROS levelsMtDNA levelsElevated expressionMtDNA quantityOxygen speciesOocytesGenesMature oocytesNumerous aspectsExpressionReproductive agingMII oocytesFollicle-enclosed oocytesSame-sex reproduction
Greenfeld DA, Seli E. Same-sex reproduction. Current Opinion In Obstetrics & Gynecology 2016, 28: 202-205. PMID: 27077473, DOI: 10.1097/gco.0000000000000266.Peer-Reviewed Original ResearchConceptsSame-sex couplesSame-sex reproductionGay menPublic acceptanceSame-sex marriageSame-sex relationshipsSame-sex unionsHeterosexual parentsGay couplesHeterosexual couplesParenthoodHistorical significanceGreat endeavorNumber of menFertility treatment centreAssisted reproductionLesbiansGayWomenMarriageUnionAcceptanceRelationship satisfactionCouplesPositive functioning
2015
Ovarian Aging
Seli E. Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 375-376. PMID: 26565386, DOI: 10.1055/s-0035-1567817.Peer-Reviewed Original ResearchOocyte mitochondrial function and reproduction
Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Current Opinion In Obstetrics & Gynecology 2015, 27: 175-181. PMID: 25719756, PMCID: PMC4590773, DOI: 10.1097/gco.0000000000000164.Peer-Reviewed Original ResearchConceptsOocyte mitochondrial functionMitochondrial functionEmbryonic developmentMitochondrial nutrientsMitochondrial replacementRole of mitochondriaOogonial stem cellsCellular organellesMammalian reproductionMitochondrial performanceMitochondrial diseaseEmbryo developmentMitochondrial activityMitochondrial dysfunctionOocyte developmentMitochondriaReproductive consequencesStem cellsOocyte maturationMitochondrial abnormalitiesPolar bodyReproductionEnergy productionIntake of compoundsNegative long-term health effects
2010
Third party reproduction and the aging couple
Luk J, Greenfeld DA, Seli E. Third party reproduction and the aging couple. Maturitas 2010, 66: 389-396. PMID: 20451337, DOI: 10.1016/j.maturitas.2010.03.024.Peer-Reviewed Original ResearchConceptsThird-party reproductionOocyte donationFirst pregnancyInfertility treatmentSignificant success rateAverage ageOocyte donorsSocial workersMore womenCommon formSuccess rateReproductive technologiesLate 30sPregnancyEarly 40sPartner's advancesAgeFemale agePartiesUnited StatesPhysical involvementDonationUterusGratifying experienceNurses