2014
Epab is dispensable for mouse spermatogenesis and male fertility
Ozturk S, Guzeloglu-Kayisli O, Lowther KM, Lalioti MD, Sakkas D, Seli E. Epab is dispensable for mouse spermatogenesis and male fertility. Molecular Reproduction And Development 2014, 81: 390-390. PMID: 24599567, PMCID: PMC4079073, DOI: 10.1002/mrd.22319.Peer-Reviewed Original Research
2012
Epab and Pabpc1 Are Differentially Expressed During Male Germ Cell Development
Ozturk S, Guzeloglu-Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti MD, Seli E. Epab and Pabpc1 Are Differentially Expressed During Male Germ Cell Development. Reproductive Sciences 2012, 19: 911-922. PMID: 22814100, PMCID: PMC4046314, DOI: 10.1177/1933719112446086.Peer-Reviewed Original ResearchConceptsRound spermatidsGene expressionMale germ cell developmentGerm cell developmentPABPC1 expressionTranslational regulationCytoplasmic polyadenylationPosttranscriptional mechanismsPABPC1Key proteinsCell developmentEPABSpatial expressionMature testesMouse testisMessenger RNASpermatogenic cellsTail lengthProteinSpermatocytesExpressionSpermatogoniaTestisEarly postnatal lifePolyadenylation
2011
The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis
Schober CS, Aydiner F, Booth CJ, Seli E, Reinke V. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Cells And Development 2011, 128: 178-190. PMID: 21277975, DOI: 10.1016/j.mod.2011.01.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChromosomes, MammalianFemaleHistonesInfertility, FemaleInfertility, MaleMaleMeiosisMiceMice, Inbred C57BLMice, Mutant StrainsMutagenesis, InsertionalOocytesOogenesisOrgan SizeOrgan SpecificityOvaryPhenotypePhosphorylationProtein Serine-Threonine KinasesSeminiferous EpitheliumSpermatogenesisTestisTumor Suppressor Protein p53ConceptsMeiotic progressionNormal meiotic progressionGene trap insertionConserved roleDrosophila oogenesisMammalian gametogenesisMammalian oogenesisVRK1 activityPhosphorylation substratesFemale meiosisInvertebrate speciesProliferation defectMale spermatogoniaChromosomal configurationsMetaphase plateVRK1OogenesisVRK1 expressionFailure of oocytesMouse strainsDrosophilaMeiosisGametogenesisChromosomesLoci
2005
The significance of sperm nuclear DNA strand breaks on reproductive outcome
Spano M, Seli E, Bizzaro D, Manicardi GC, Sakkas D. The significance of sperm nuclear DNA strand breaks on reproductive outcome. Current Opinion In Obstetrics & Gynecology 2005, 17: 255-260. PMID: 15870559, DOI: 10.1097/01.gco.0000169102.77504.66.Peer-Reviewed Original ResearchConceptsNuclear DNA strand breaksDNA strand breaksStrand breaksDNA abnormalitiesPaternal genomeChromatin structureNuclear DNASperm nuclear DNASperm nucleiSperm chromatin structureNuclear abnormalitiesReproductive parametersBlastocyst developmentSpermatozoaBody of evidenceNuclear anomaliesGenomeDNA anomaliesBreaksDNAReproductionSpermatogenesisAssisted reproduction technologyFertilizationReproductive outcomes
2004
The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail?
Sakkas D, Seli E, Manicardi GC, Nijs M, Ombelet W, Bizzaro D. The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail? Human Fertility 2004, 7: 99-103. PMID: 15223758, DOI: 10.1080/14647270410001720464.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCell NucleusDNA DamageDNA FragmentationEjaculationHumansMaleSpermatogenesisSpermatozoaConceptsIntracytoplasmic sperm injectionNuclear DNA strand breaksDNA strand breaksAbnormal semen parametersAbnormal spermatozoaInfertile couplesMale infertilitySperm injectionSemen parametersQuality of spermatozoaAssisted reproductionStrand breaksCertain causesHuman spermatozoaSuch spermApoptosisSuccessful useNumerous studiesSpermatozoaPatients
2003
Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis
Sakkas D, Seli E, Bizzaro D, Tarozzi N, Manicardi GC. Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reproductive BioMedicine Online 2003, 7: 428-432. PMID: 14656403, DOI: 10.1016/s1472-6483(10)61886-x.Peer-Reviewed Original ResearchConceptsNuclear DNA strand breaksDNA strand breaksAbnormal semen parametersAbnormal spermatozoaMale infertilitySemen parametersAbnormal persistenceApoptotic marker proteinsStrand breaksCertain causesHuman spermatozoaMarker proteinsApoptosisNumerous studiesSpermatogenesisSpermatozoaHumansInfertilityAbnormalities