2021
B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population
Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertility And Sterility 2021, 117: 351-358. PMID: 34809978, DOI: 10.1016/j.fertnstert.2021.09.036.Peer-Reviewed Original ResearchConceptsB-cell lymphoma 6 (Bcl6) expressionLive birth groupLive birthsFertilization populationNormal respondersBirth groupProportion of patientsLive birth ratePopulation of patientsEuploid embryo transferCase-control studyEndometrial tissue samplesPreimplantation genetic testingGroup of womenIVF stimulationMean HSCOREIVF outcomesInfertility centerIVF successMAIN OUTCOMEGroup 2Group 1Embryo transferPatientsClinical decisionNoninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy
Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertility And Sterility 2021, 115: 1461-1470. PMID: 33745720, DOI: 10.1016/j.fertnstert.2021.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyBlastocystCulture MediaEmbryo Culture TechniquesEmbryo ImplantationEmbryo TransferFemaleFertilityHigh-Throughput Nucleotide SequencingHumansInfertilityLive BirthMaleNoninvasive Prenatal TestingNucleic Acid Amplification TechniquesPredictive Value of TestsPregnancyPregnancy RatePreimplantation DiagnosisReproducibility of ResultsSperm Injections, IntracytoplasmicTime FactorsTreatment OutcomeWhole Genome SequencingConceptsPreimplantation genetic testingGenetic testingBiopsy resultsProspective cohort study SETTINGTrophectoderm biopsyTE biopsyNoninvasive preimplantation genetic testingCohort study SETTINGNext-generation sequencingHigh ratePrimary outcomeClinical outcomesMAIN OUTCOMEBiopsyStudy settingAmplification failureDiscordant resultsClinical applicabilityPrivate practiceNiPGTAvailable kitsCulture mediumShort durationOutcomesCulture medium samples
2020
Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency
Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, Tiras B, Seli E. Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency. Aging 2020, 12: 10211-10222. PMID: 32507764, PMCID: PMC7346073, DOI: 10.18632/aging.103403.Peer-Reviewed Original ResearchConceptsAutologous platelet-rich plasmaPrimary ovarian insufficiencyPlatelet-rich plasmaIVF outcome parametersAntral follicle countIntraovarian injectionOvarian reservePRP injectionAntimullerian hormoneOutcome parametersOvarian insufficiencyRich plasmaSerum antimullerian hormoneUnderwent embryo transferExperimental treatment optionsESHRE criteriaSustained implantationOvarian stimulationSerum follicleFollicle countPRP treatmentTreatment optionsFertilization outcomeAntral folliclesEmbryo transferKey metrics and processes for validating embryo diagnostics
Jalas C, Seli E, Scott RT. Key metrics and processes for validating embryo diagnostics. Fertility And Sterility 2020, 114: 16-23. PMID: 32505382, DOI: 10.1016/j.fertnstert.2020.04.053.Peer-Reviewed Original ResearchSperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes
Tiegs AW, Tao X, Landis J, Zhan Y, Franasiak JM, Seli E, Wells D, Fragouli E, Scott RT. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reproductive Sciences 2020, 27: 1350-1356. PMID: 31994001, DOI: 10.1007/s43032-020-00163-0.Peer-Reviewed Original ResearchConceptsSperm mitochondrial DNA copy numberLive birth rateQuantitative real-time polymerase chain reactionMitochondrial DNA copy numberICSI cyclesBirth rateIntracytoplasmic sperm injection cycle outcomesBlastocyst developmentDay-3 embryo biopsyMtDNA-CNDNA copy numberBlastocyst euploidy ratesMixed-effects logistic regressionReal-time polymerase chain reactionSperm samplesEffects logistic regressionBlastocyst euploidyCohort studyPrimary outcomeSecondary outcomesInfertility centerCycle outcomeEuploidy rateMaternal ageInfertile population
2019
Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis
Sofiyeva N, Siepmann T, Barlinn K, Seli E, Ata B. Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis. Reproductive Sciences 2019, 26: 939-953. PMID: 30270741, DOI: 10.1177/1933719118799203.Peer-Reviewed Original ResearchConceptsGonadotropin-releasing hormone analogueSystematic reviewGonadotoxic chemotherapyHormone analogueRisk ratioGnRH agonist-treated patientsGonadotropin-Releasing Hormone AnalogLow-quality evidenceReproductive-aged womenConfidence intervalsSignificant protective effectGonadoprotective effectPresent systematic reviewGnRHa cotreatmentGonadal protectionSupradiaphragmatic radiotherapyCohort studyTrials RegistryGnRHa administrationMenstrual resumptionAutoimmune diseasesSubgroup analysisBreast cancerProtective effectHematological malignanciesMetabolic imaging via fluorescence lifetime imaging microscopy for egg and embryo assessment
Sanchez T, Zhang M, Needleman D, Seli E. Metabolic imaging via fluorescence lifetime imaging microscopy for egg and embryo assessment. Fertility And Sterility 2019, 111: 212-218. PMID: 30691624, DOI: 10.1016/j.fertnstert.2018.12.014.Peer-Reviewed Original ResearchConceptsMetabolic imagingInvasive diagnostic interventionsEmbryo assessmentPreimplantation genetic testingUseful diagnostic methodAssisted reproductive technology (ART) laboratoryClinical benefitSingle ETDiagnostic interventionsOxidative phosphorylationGenetic testingReproductive technology laboratoriesExperimental modelCopy number assessmentMetabolic functionsMorphologic parametersFluorescence lifetimeEmbryosClinical applicationMetabolic stateDiagnostic methodsEmbryo viabilityElectron transporterCentral roleCurrent strategies
2018
Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance
Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAneuploidyBlastomeresDatabases, FactualEmbryo Culture TechniquesEmbryo TransferFemaleFertility Agents, FemaleFertilization in VitroHumansInfertility, FemaleLive BirthOvarian ReserveOvaryOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeConceptsPoor oocyte qualityOvarian reserveLive birth rateDiminished ovarian reserveOocyte yieldOocyte qualityBlastulation rateAMH levelsPoor respondersPoor responseFollicular depletionBirth rateEmbryo transferAneuploidy rateLower live birth ratesYoung womenSTUDY FUNDING/COMPETINGGood prognosis patientsOvarian reserve parametersOvarian reserve testingYoung poor respondersPoor ovarian responseRetrospective cohort studyLower oocyte yieldInterquartile range
2016
Mitochondrial DNA as a biomarker for in-vitro fertilization outcome
Seli E. Mitochondrial DNA as a biomarker for in-vitro fertilization outcome. Current Opinion In Obstetrics & Gynecology 2016, 28: 158-163. PMID: 27077472, DOI: 10.1097/gco.0000000000000274.Peer-Reviewed Original Research
2015
Oocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss
Cil AP, Turkgeldi L, Seli E. Oocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss. Seminars In Reproductive Medicine 2015, 33: 429-435. PMID: 26562287, DOI: 10.1055/s-0035-1567819.Peer-Reviewed Original ResearchConceptsAge-related declineOocyte cryopreservationAge-related fertility lossGood ovarian reserveFertility preservation strategiesPublic health campaignsPreconceptional counselingOvarian reserveAdvanced ageHealth campaignsPreventive measuresHealth informationMedical professionalsLater stagesWomenYoung adolescentsPreservation strategiesPatientsFertility lossIncidencePublic awarenessStrategies for Controlled Ovarian Stimulation in the Setting of Ovarian Aging
Ata B, Seli E. Strategies for Controlled Ovarian Stimulation in the Setting of Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 436-448. PMID: 26562286, DOI: 10.1055/s-0035-1567818.Peer-Reviewed Original ResearchConceptsControlled ovarian stimulationOvarian agingOvarian stimulationPossible side effects profileShort GnRH agonist protocolGonadotropin-releasing hormone antagonistGnRH agonist protocolTotal gonadotropin consumptionIU/daySide effect profileCost of medicationsGrowth hormone supplementationHigh-quality evidenceTransdermal testosterone administrationDuration of stimulationQuality of oocytesAppropriate first choiceAgonist protocolCOS protocolsEstradiol primingGonadotropin consumptionGonadotropin dosageEffect profileHormone antagonistHormone supplementation
2008
Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization
Seli E, Botros L, Sakkas D, Burns DH. Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertility And Sterility 2008, 90: 2183-2189. PMID: 18842260, DOI: 10.1016/j.fertnstert.2008.07.1739.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCulture MediaEmbryo Culture TechniquesEmbryo ImplantationEmbryo TransferEmbryo, MammalianEmbryonic DevelopmentFemaleFertilization in VitroHumansLive BirthMagnetic Resonance SpectroscopyMetabolomicsPredictive Value of TestsPregnancyPregnancy RateProtonsRetrospective StudiesSensitivity and SpecificityTreatment OutcomeConceptsEmbryo culture mediumNoninvasive metabolomic profilingMetabolomic profilesMetabolomic profilingReproductive technology programViability indexNuclear magnetic resonance metabolomic profilingRetrospective studyART treatmentMAIN OUTCOMEReproductive outcomesCulture mediumDay 3NMR metabolomic profilesGlutamate concentrationMultivariate analysisPregnancy
2006
Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
Daftary GS, Kayisli U, Seli E, Bukulmez O, Arici A, Taylor HS. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertility And Sterility 2006, 87: 367-372. PMID: 17173899, DOI: 10.1016/j.fertnstert.2006.06.041.Peer-Reviewed Original ResearchConceptsEndometrial HOXA10 expressionImplantation rateHOXA10 expressionInfertile womenFertile controlsHOXA10 mRNAPolymerase chain reaction findingsProspective clinical trialsReal-time reverse transcription-polymerase chain reactionReverse transcription-polymerase chain reactionHOXA10 protein expressionExpression of HOXA10Academic medical centerHOXA10 mRNA expressionGlandular epithelial cellsHomeobox gene HOXA10Potential molecular mechanismsBilateral hydrosalpinxHydrosalpinx fluidEndometrial stromaMidluteal phasePolymerase chain reactionClinical trialsSalpingectomyMedical Center