2022
Distress response in granulosa cells of women affected by PCOS with or without insulin resistance
Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGranulosa CellsHumansInsulin ResistancePolycystic Ovary SyndromeProtein Serine-Threonine KinasesTumor MicroenvironmentConceptsPolycystic ovarian syndromeHomeostasis model assessmentPCOS-IRInsulin resistanceHealthy oocyte donorsCumulus GCsOvarian syndromePCOS groupPlasma glucoseCONT groupMetabolic dysfunctionPathological changesFollicular microenvironmentConclusionOur findingsOocyte donorsGranulosa cellsModel assessmentQRT-PCRWomenER stressCONTMolecular mechanismsCell stressDistress responsesGroup
2011
The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis
Schober CS, Aydiner F, Booth CJ, Seli E, Reinke V. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Cells And Development 2011, 128: 178-190. PMID: 21277975, DOI: 10.1016/j.mod.2011.01.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChromosomes, MammalianFemaleHistonesInfertility, FemaleInfertility, MaleMaleMeiosisMiceMice, Inbred C57BLMice, Mutant StrainsMutagenesis, InsertionalOocytesOogenesisOrgan SizeOrgan SpecificityOvaryPhenotypePhosphorylationProtein Serine-Threonine KinasesSeminiferous EpitheliumSpermatogenesisTestisTumor Suppressor Protein p53ConceptsMeiotic progressionNormal meiotic progressionGene trap insertionConserved roleDrosophila oogenesisMammalian gametogenesisMammalian oogenesisVRK1 activityPhosphorylation substratesFemale meiosisInvertebrate speciesProliferation defectMale spermatogoniaChromosomal configurationsMetaphase plateVRK1OogenesisVRK1 expressionFailure of oocytesMouse strainsDrosophilaMeiosisGametogenesisChromosomesLoci