2021
Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences
Yang M, Tao X, Scott K, Zhan Y, Scott RT, Seli E. Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences. Human Reproduction 2021, 36: 1682-1690. PMID: 33846747, DOI: 10.1093/humrep/deab074.Peer-Reviewed Original ResearchConceptsWhole-genome bisulfite sequencingDNA methylation profilesGenome-wide DNA methylation levelsGenome-wide DNA methylation profilesGenome-wide methylation levelsDNA methylation levelsMethylation profilesMethylation levelsDNA methylationGenome-wide DNA methylome analysisWhole-genome sequencing librariesDifferent DNA methylation profilesEpigenetic regulatory mechanismsDifferent developmental potentialEmbryonic competenceDNA methylome analysisPre-implantation embryo developmentInvolved chromosomeTrophectoderm biopsy samplesDifferentiation of cellsHuman preimplantation embryosCopy number varianceChromosomal scaleLower methylation levelsEmbryo identity
2020
Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model
Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT, Seli EU. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Human Reproduction 2020, 35: 2579-2588. PMID: 33049778, DOI: 10.1093/humrep/deaa206.Peer-Reviewed Original ResearchMeSH KeywordsAccelerationDNA MethylationEpigenesis, GeneticFemaleHumansLeukocytesOvaryOvulation InductionProspective StudiesConceptsPoor ovarian responseWhite blood cellsPolycystic ovary syndromeOvarian responseOvarian stimulationChronologic ageWBC samplesEpigenetic age accelerationCumulus cellsAge accelerationYoung womenSTUDY FUNDING/COMPETINGBlood cellsProspective cohort studyGood responder groupCommon clinical challengePeripheral blood samplesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of agePatient's chronologic ageGeneral health consequencesCC samplesAge-related changesAge prediction model
2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescence
2014
The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders
Uyar A, Seli E. The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders. Current Opinion In Obstetrics & Gynecology 2014, 26: 210-221. PMID: 24752003, PMCID: PMC4123998, DOI: 10.1097/gco.0000000000000071.Peer-Reviewed Original ResearchConceptsRelevant clinical dataReproductive technology proceduresConclusive clinical trialsBeckwith-Wiedemann syndromeCase seriesLarge registriesClinical trialsART proceduresClinical dataHigh prevalenceGeneral populationLow prevalenceART usePotential associationGenomic imprintingGene expressionDisordersEarly embryo developmentReproductive technologiesAllele-specific gene expressionFurther studiesTechnology proceduresPrevalenceImprinted gene expressionImprinting disorders