2020
Mitochondrial function in women with polycystic ovary syndrome.
Cozzolino M, Seli E. Mitochondrial function in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2020, 32: 205-212. PMID: 32068544, DOI: 10.1097/gco.0000000000000619.Peer-Reviewed Original ResearchMeSH KeywordsDNA, MitochondrialFemaleHumansInsulin ResistanceMitochondriaMutationObesityOxidative StressPolycystic Ovary SyndromePolymorphism, Single NucleotidePregnancyUnfolded Protein ResponseConceptsPolycystic ovary syndromeLower mtDNA copy numberOvary syndromePathogenesis of PCOSMitochondrial dysfunctionMtDNA copy numberPotential protective rolePCOS phenotypeInsulin resistancePathophysiological mechanismsCommon findingDiagnostic modalitiesMetabolic milieuFunctional alterationsMitochondrial functional alterationsProtective roleCommon diseaseOxidative stressWomenMitochondrial functionDysfunctionSyndromeCopy numberProtein responseReactive oxygen
2008
Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte
Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD. Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte. Molecular Human Reproduction 2008, 14: 393-398. PMID: 18492745, PMCID: PMC2453241, DOI: 10.1093/molehr/gan028.Peer-Reviewed Original ResearchConceptsExonic splicing enhancersAlternative splicing variantsSingle nucleotide polymorphismsAlternative splicingSplicing variantsSplicing enhancersExon 10Post-transcriptional controlMRNA alternative splicingEarly preimplantation embryosOocyte-specific proteinRNA editingMaternal mRNAsEarly embryosMouse embryonicBinding protein mRNAReal-time RT-PCR resultsGene expressionPreimplantation embryosSpliced formsSame locusSequence analysisBinding proteinSplicingParental origin