2024
Poor ovarian response classification systems in the clinical setting – time for an update?
Reig A, Seli E. Poor ovarian response classification systems in the clinical setting – time for an update? Current Opinion In Obstetrics & Gynecology 2024, 36: 192-199. PMID: 38597510, DOI: 10.1097/gco.0000000000000950.Peer-Reviewed Original ResearchMeSH KeywordsEmbryo TransferFemaleFertilization in VitroHumansInfertility, FemaleOocyte RetrievalOvarian ReserveOvaryOvulation InductionPregnancyReproductive Techniques, AssistedConceptsPoor ovarian responseOvarian responsePoor ovarian response definitionDefinition of poor ovarian responseSuccess of assisted reproductive technologiesEra of personalized medicineOvarian reserve markersAssisted reproductive technologyBologna criteriaEuploid embryosReserve markersReproductive technologyClassification systemDiagnostic criteriaPersonalized medicineCounseling toolEffective predictor
2021
Editorial: Assisted reproductive technology (ART) in a changing world
Seli E, Garcia-Velasco JA. Editorial: Assisted reproductive technology (ART) in a changing world. Current Opinion In Obstetrics & Gynecology 2021, 33: 157-158. PMID: 33896914, DOI: 10.1097/gco.0000000000000699.Peer-Reviewed Original Research
2020
Key metrics and processes for validating embryo diagnostics
Jalas C, Seli E, Scott RT. Key metrics and processes for validating embryo diagnostics. Fertility And Sterility 2020, 114: 16-23. PMID: 32505382, DOI: 10.1016/j.fertnstert.2020.04.053.Peer-Reviewed Original ResearchMeSH KeywordsEmbryo, MammalianFemaleHumansInfertilityPregnancyPreimplantation DiagnosisQuality Indicators, Health CareReproductive Techniques, AssistedTreatment OutcomeValidation Studies as TopicEditorial: Challenges in ART diagnostics.
Garcia Velasco JA, Seli E. Editorial: Challenges in ART diagnostics. Current Opinion In Obstetrics & Gynecology 2020, 32: 167-168. PMID: 32168032, DOI: 10.1097/gco.0000000000000622.Peer-Reviewed Original ResearchMitochondrial Dysfunction and Ovarian Aging
Kasapoğlu I, Seli E. Mitochondrial Dysfunction and Ovarian Aging. Endocrinology 2020, 161: bqaa001. PMID: 31927571, DOI: 10.1210/endocr/bqaa001.Peer-Reviewed Original Research
2019
Diminished ovarian reserve versus ovarian aging: overlaps and differences.
Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences. Current Opinion In Obstetrics & Gynecology 2019, 31: 139-147. PMID: 30870184, DOI: 10.1097/gco.0000000000000536.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultAgingAneuploidyBlastocystChromosome AberrationsFemaleFertilizationHumansInfertility, FemaleOocytesOvarian ReserveOvaryPregnancyReproductive Techniques, AssistedYoung AdultConceptsNormal ovarian reserveOvarian reservePregnancy lossOocyte qualityReproductive technology cyclesAge-matched womenDiminished ovarian reserveLow ovarian reserveFetal chromosomal abnormalitiesQuantitative declineFecundity of womenOvarian stimulationNatural conceptionOvarian agingPoor responseART treatmentAged womenYoung womenChromosomal abnormalitiesAvailable evidenceDecreased numberQualitative declineOocyte poolWomenBlastocyst developmentThe association between assisted reproductive technologies and low birth weight.
Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Current Opinion In Obstetrics & Gynecology 2019, 31: 183-187. PMID: 30893135, DOI: 10.1097/gco.0000000000000535.Peer-Reviewed Original ResearchConceptsLow birth weightFresh embryo transferFrozen embryo transferBirth weightNumber of embryosEmbryo transferReproductive technologiesART-conceived pregnanciesComparable birth weightMain risk factorsEndometrial preparationPerinatal outcomesMultiple gestationsRisk factorsAssisted reproductionPrematurityNewbornsIncidenceRecent studiesPregnancyGestationWeightMitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging
Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseTwo-cell embryo developmentUnfolded protein responseImpaired oocyte maturationMorphology of mitochondriaMitochondrial dysfunction resultsPremature reproductive agingNovel mechanistic insightsMitochondrial DNA contentReactive oxygen species productionPrevention of agingCLPP resultsProtein responseOxygen species productionReproductive agingPreimplantation embryosAge-related accumulationOxidative phosphorylationStress responseEmbryo developmentForm blastocystsMitochondrial functionMitochondriaMitochondrial dysfunctionEnergy metabolism
2018
How new technical knowledge impacts clinical approach to infertile patients
García-Velasco JA, Seli E. How new technical knowledge impacts clinical approach to infertile patients. Current Opinion In Obstetrics & Gynecology 2018, 30: 137-138. PMID: 29652726, DOI: 10.1097/gco.0000000000000461.Peer-Reviewed Original ResearchBiomedical ResearchBiomedical TechnologyClinical Studies as TopicFemaleHumansInfertilityInfertility, FemaleInfertility, MaleMaleReproductive Techniques, AssistedMetabolism of the oocyte and the preimplantation embryo
Scott R, Zhang M, Seli E. Metabolism of the oocyte and the preimplantation embryo. Current Opinion In Obstetrics & Gynecology 2018, 30: 163-170. PMID: 29708901, DOI: 10.1097/gco.0000000000000455.Peer-Reviewed Original ResearchMeSH KeywordsBlastocystEmbryonic DevelopmentEnergy MetabolismFemaleFertilization in VitroGenitalia, FemaleGlucoseHumansLactic AcidOocytesPyruvic AcidReproductive Techniques, AssistedAssisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications
Morin SJ, Seli E. Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications. Seminars In Reproductive Medicine 2018, 36: 195-203. PMID: 30866006, DOI: 10.1055/s-0038-1677048.Peer-Reviewed Original ResearchMeSH KeywordsChild DevelopmentFemaleHumansInfant, NewbornInfertility, FemaleInfertility, MaleMalePregnancyPregnancy OutcomeReproductive Techniques, AssistedResearch DesignRisk AssessmentConceptsSevere male factor infertilityART-exposed childrenLow birth weightMale factor infertilityReproductive technologiesSevere monogenic disordersAssisted Reproductive TechnologyMultiple gestationsSubfertile womenFactor infertilityMetabolic derangementsPremature birthAbsolute riskBirth weightCardiovascular diseaseAdditional diagnosisNumber of womenClinical realityMultiple studiesMonogenic disordersNumber of couplesRiskOrigin of diseaseDiseaseWomenThe role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights
Cecchino GN, Seli E, Alves da Motta E, García-Velasco J. The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive BioMedicine Online 2018, 36: 686-697. PMID: 29598846, DOI: 10.1016/j.rbmo.2018.02.007.Peer-Reviewed Original ResearchMeSH KeywordsDNA, MitochondrialFemaleFertilityHumansMitochondriaOocytesReproductive Techniques, AssistedConceptsMetabolic stress modelsMitochondrial functionFemale fertilityFemale reproductive processesPoor outcomeReplacement therapyOvarian agingMitochondrial DNA contentInfertility treatmentTherapeutic attemptsOocyte qualityClinical implicationsEmbryo potentialOocyte maturationReproductive processesPrecursor cellsEarly embryo developmentReproductive technologiesDisease-causing mutationsMitochondrial capacityRole of mitochondriaMitochondrial impactCurrent insightsTrophectoderm cellsWomen
2017
A universal freeze all strategy
Ata B, Seli E. A universal freeze all strategy. Current Opinion In Obstetrics & Gynecology 2017, 29: 136-145. PMID: 28333696, DOI: 10.1097/gco.0000000000000362.Peer-Reviewed Original ResearchMeSH KeywordsCost-Benefit AnalysisCryopreservationEmbryo TransferFemaleHumansPregnancyPregnancy ComplicationsRandomized Controlled Trials as TopicReproductive Techniques, AssistedConceptsElective frozen embryo transferFrozen embryo transferOvarian responseEmbryo transferPatient/physician preferenceReproductive technology cyclesLow ovarian responseLive birth rateMultifollicular growthHypertensive disordersOvarian stimulationPerinatal outcomesPlacenta accretaUnstimulated cyclesNew RCTsPerinatal mortalityPreclinical evidenceSerious complicationsEndometrial functionClinical evidenceRetrospective studyPhysician preferenceContradictory resultsExcessive responseAdverse effects
2016
Same-sex reproduction
Greenfeld DA, Seli E. Same-sex reproduction. Current Opinion In Obstetrics & Gynecology 2016, 28: 202-205. PMID: 27077473, DOI: 10.1097/gco.0000000000000266.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHomosexuality, FemaleHomosexuality, MaleHumansMaleMarriageParentsPregnancyPublic OpinionReproductionReproductive Techniques, AssistedConceptsSame-sex couplesSame-sex reproductionGay menPublic acceptanceSame-sex marriageSame-sex relationshipsSame-sex unionsHeterosexual parentsGay couplesHeterosexual couplesParenthoodHistorical significanceGreat endeavorNumber of menFertility treatment centreAssisted reproductionLesbiansGayWomenMarriageUnionAcceptanceRelationship satisfactionCouplesPositive functioning
2015
Ovarian Aging
Seli E. Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 375-376. PMID: 26565386, DOI: 10.1055/s-0035-1567817.Peer-Reviewed Original ResearchOocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss
Cil AP, Turkgeldi L, Seli E. Oocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss. Seminars In Reproductive Medicine 2015, 33: 429-435. PMID: 26562287, DOI: 10.1055/s-0035-1567819.Peer-Reviewed Original ResearchConceptsAge-related declineOocyte cryopreservationAge-related fertility lossGood ovarian reserveFertility preservation strategiesPublic health campaignsPreconceptional counselingOvarian reserveAdvanced ageHealth campaignsPreventive measuresHealth informationMedical professionalsLater stagesWomenYoung adolescentsPreservation strategiesPatientsFertility lossIncidencePublic awarenessOocyte mitochondrial function and reproduction
Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Current Opinion In Obstetrics & Gynecology 2015, 27: 175-181. PMID: 25719756, PMCID: PMC4590773, DOI: 10.1097/gco.0000000000000164.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEnergy MetabolismFemaleGonadsHumansMiceMitochondriaOocytesPregnancyReproductionReproductive Techniques, AssistedSwineConceptsOocyte mitochondrial functionMitochondrial functionEmbryonic developmentMitochondrial nutrientsMitochondrial replacementRole of mitochondriaOogonial stem cellsCellular organellesMammalian reproductionMitochondrial performanceMitochondrial diseaseEmbryo developmentMitochondrial activityMitochondrial dysfunctionOocyte developmentMitochondriaReproductive consequencesStem cellsOocyte maturationMitochondrial abnormalitiesPolar bodyReproductionEnergy productionIntake of compoundsNegative long-term health effects
2014
The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders
Uyar A, Seli E. The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders. Current Opinion In Obstetrics & Gynecology 2014, 26: 210-221. PMID: 24752003, PMCID: PMC4123998, DOI: 10.1097/gco.0000000000000071.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeckwith-Wiedemann SyndromeDNA MethylationEpigenesis, GeneticFemaleGenomic ImprintingHumansInfant, NewbornInfertilityMaleMicePregnancyReproductive Techniques, AssistedRisk FactorsConceptsRelevant clinical dataReproductive technology proceduresConclusive clinical trialsBeckwith-Wiedemann syndromeCase seriesLarge registriesClinical trialsART proceduresClinical dataHigh prevalenceGeneral populationLow prevalenceART usePotential associationGenomic imprintingGene expressionDisordersEarly embryo developmentReproductive technologiesAllele-specific gene expressionFurther studiesTechnology proceduresPrevalenceImprinted gene expressionImprinting disorders
2012
The association between fertility clinic performance and cycle volume: implications for public reporting of provider performance data
Gong D, Seli E. The association between fertility clinic performance and cycle volume: implications for public reporting of provider performance data. Fertility And Sterility 2012, 98: 55-62.e1. PMID: 22521157, DOI: 10.1016/j.fertnstert.2012.03.036.Peer-Reviewed Original ResearchConceptsLive birth rateProvider performance dataClinic performanceSuccess rateCycle volumeReproductive technology clinicsRetrospective longitudinal analysisHealth care providersBirth ratePublic reportingART cyclesPregnancy rateART treatmentStudy populationMAIN OUTCOMECare providersStratification analysisTechnology clinicsPatient behaviorClinicDisease controlPublic quality reportingPatientsProvider performanceLongitudinal analysis
2011
Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis
Bromer JG, Ata B, Seli M, Lockwood CJ, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Current Opinion In Obstetrics & Gynecology 2011, 23: 168-173. PMID: 21372712, DOI: 10.1097/gco.0b013e32834551cd.Peer-Reviewed Original ResearchMeSH KeywordsCosts and Cost AnalysisFemaleHumansInfant, NewbornPregnancyPregnancy, MultiplePremature BirthReproductive Techniques, AssistedConceptsMultiple pregnanciesPreterm deliveryPreterm infantsNumber of embryosInfant deliveryAssisted reproductive technology cyclesElective single embryo transferART live birthsReproductive technology cyclesSingle embryo transferFinancial burdenART neonatesART twinsMedical complicationsART cyclesLive birthsSubstantial burdenMean costPregnancyEmbryo transferART tripletsInfantsHealthcare expendituresHealth science policyReproductive technologies