Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes
Tiegs AW, Tao X, Landis J, Zhan Y, Franasiak JM, Seli E, Wells D, Fragouli E, Scott RT. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reproductive Sciences 2020, 27: 1350-1356. PMID: 31994001, DOI: 10.1007/s43032-020-00163-0.Peer-Reviewed Original ResearchConceptsSperm mitochondrial DNA copy numberLive birth rateQuantitative real-time polymerase chain reactionMitochondrial DNA copy numberICSI cyclesBirth rateIntracytoplasmic sperm injection cycle outcomesBlastocyst developmentDay-3 embryo biopsyMtDNA-CNDNA copy numberBlastocyst euploidy ratesMixed-effects logistic regressionReal-time polymerase chain reactionSperm samplesEffects logistic regressionBlastocyst euploidyCohort studyPrimary outcomeSecondary outcomesInfertility centerCycle outcomeEuploidy rateMaternal ageInfertile population