2020
Mitochondrial function in women with polycystic ovary syndrome.
Cozzolino M, Seli E. Mitochondrial function in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2020, 32: 205-212. PMID: 32068544, DOI: 10.1097/gco.0000000000000619.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLower mtDNA copy numberOvary syndromePathogenesis of PCOSMitochondrial dysfunctionMtDNA copy numberPotential protective rolePCOS phenotypeInsulin resistancePathophysiological mechanismsCommon findingDiagnostic modalitiesMetabolic milieuFunctional alterationsMitochondrial functional alterationsProtective roleCommon diseaseOxidative stressWomenMitochondrial functionDysfunctionSyndromeCopy numberProtein responseReactive oxygenMitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts
Scott RT, Sun L, Zhan Y, Marin D, Tao X, Seli E. Mitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts. Reproductive BioMedicine Online 2020, 41: 183-190. PMID: 32600944, DOI: 10.1016/j.rbmo.2020.04.011.Peer-Reviewed Original ResearchConceptsRelative mtDNA copy numberSingle embryo transferMitochondrial DNA copy numberMtDNA copy numberEmbryo transferSuccessful single embryo transferDNA copy numberRelative mtDNA levelsHuman blastocystsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionReproductive competenceIVF outcomesMaternal ageOngoing implantationPolymerase chain reactionEuploid blastocystsMitochondrial DNA contentReproductive outcomesSame patientClinical decisionTrophectoderm biopsySame cohortAmount of mtDNACopy numberSperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes
Tiegs AW, Tao X, Landis J, Zhan Y, Franasiak JM, Seli E, Wells D, Fragouli E, Scott RT. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reproductive Sciences 2020, 27: 1350-1356. PMID: 31994001, DOI: 10.1007/s43032-020-00163-0.Peer-Reviewed Original ResearchConceptsSperm mitochondrial DNA copy numberLive birth rateQuantitative real-time polymerase chain reactionMitochondrial DNA copy numberICSI cyclesBirth rateIntracytoplasmic sperm injection cycle outcomesBlastocyst developmentDay-3 embryo biopsyMtDNA-CNDNA copy numberBlastocyst euploidy ratesMixed-effects logistic regressionReal-time polymerase chain reactionSperm samplesEffects logistic regressionBlastocyst euploidyCohort studyPrimary outcomeSecondary outcomesInfertility centerCycle outcomeEuploidy rateMaternal ageInfertile population
2019
Mitochondria as a Biomarker for IVF Outcome
Kim J, Seli E. Mitochondria as a Biomarker for IVF Outcome. Reproduction 2019, -1: r235-r242. PMID: 30844752, DOI: 10.1530/rep-18-0580.Peer-Reviewed Original ResearchConceptsKey cellular functionsAcid metabolismAmino acid metabolismCellular functionsMitochondrial DNASignal transductionFatty acid metabolismApoptotic regulationIon homeostasisEmbryo developmentMitochondrial contentInfertility treatment outcomesEmbryo metabolismAdvanced maternal ageMitochondriaEssential roleEmbryo viabilityIVF outcomesImplantation failureMaternal ageEuploid blastocystsTreatment outcomesAdditional biomarkersImplantation successMetabolism
2018
The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights
Cecchino GN, Seli E, Alves da Motta E, García-Velasco J. The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive BioMedicine Online 2018, 36: 686-697. PMID: 29598846, DOI: 10.1016/j.rbmo.2018.02.007.Peer-Reviewed Original ResearchMeSH KeywordsDNA, MitochondrialFemaleFertilityHumansMitochondriaOocytesReproductive Techniques, AssistedConceptsMetabolic stress modelsMitochondrial functionFemale fertilityFemale reproductive processesPoor outcomeReplacement therapyOvarian agingMitochondrial DNA contentInfertility treatmentTherapeutic attemptsOocyte qualityClinical implicationsEmbryo potentialOocyte maturationReproductive processesPrecursor cellsEarly embryo developmentReproductive technologiesDisease-causing mutationsMitochondrial capacityRole of mitochondriaMitochondrial impactCurrent insightsTrophectoderm cellsWomen
2016
Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity
Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E. Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas 2016, 93: 121-130. PMID: 27523387, PMCID: PMC5064871, DOI: 10.1016/j.maturitas.2016.06.015.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesUnfolded protein response genesProtein response genesMitochondrial DNAMitochondrial dynamicsMitochondrial stressResponse genesMammalian reproductionMitochondria morphologyStressful conditionsMitochondrial changesMitochondriaROS levelsMtDNA levelsElevated expressionMtDNA quantityOxygen speciesOocytesGenesMature oocytesNumerous aspectsExpressionReproductive agingMII oocytesFollicle-enclosed oocytesMitochondrial DNA as a biomarker for in-vitro fertilization outcome
Seli E. Mitochondrial DNA as a biomarker for in-vitro fertilization outcome. Current Opinion In Obstetrics & Gynecology 2016, 28: 158-163. PMID: 27077472, DOI: 10.1097/gco.0000000000000274.Peer-Reviewed Original Research