2021
A review of the pathophysiology of recurrent implantation failure
Franasiak JM, Alecsandru D, Forman EJ, Gemmell LC, Goldberg JM, Llarena N, Margolis C, Laven J, Schoenmakers S, Seli E. A review of the pathophysiology of recurrent implantation failure. Fertility And Sterility 2021, 116: 1436-1448. PMID: 34674825, DOI: 10.1016/j.fertnstert.2021.09.014.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureImplantation failureMaternal immune systemReproductive tract microbiomeLack of implantationEndometrial synchronyHematologic factorsAnatomic factorsEndocrine milieuReceptive endometriumMaternal interfaceEmbryo transferImmune systemApparent treatmentCompetent blastocystClinical phenomenaHuman reproductionPotential causesImplantationFailureReviewCross talkEndometriumPatientsFactors
2014
mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium
Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsTNF-α expressionTIA-1 expressionEndometrial stromal cellsIL-6Pathogenesis of endometriosisMenstrual cycleTIA-1Endometrial tissueEctopic endometriumImmune factorsHistological scoresCultured human endometrial stromal cellsSteroid hormonesStromal cellsGrowth factorElevated IL-6Ectopic endometrial tissueNormal menstrual cycleEutopic endometrial tissuesGrowth factor expressionT-cell intracellular antigenEndometrial cytokinesEndometrial functionControl women
2011
The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium
Karipcin FS, Ensari TA, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium. Reproductive Sciences 2011, 18: 145-155. PMID: 20889954, PMCID: PMC3343139, DOI: 10.1177/1933719110382307.Peer-Reviewed Original ResearchConceptsEctopic endometriumMenstrual cycleSecretory phaseCytokine expressionHuR expressionNormal endometriumCultured endometrial stromal cellsStromal cellsEctopic endometrial cellsEctopic human endometriumMid-menstrual phaseElevated cytokine levelsEndometrial stromal cellsLate secretory phasePathogenesis of endometriosisCultured stromal cellsTumor necrosis factorMessenger RNACytokine levelsEndometrial cellsEutopic endometriumHuman endometriumNecrosis factorEndometriumEndometriosis
2003
Pathogenesis of endometriosis
Seli E, Berkkanoglu M, Arici A. Pathogenesis of endometriosis. Obstetrics And Gynecology Clinics Of North America 2003, 30: 41-61. PMID: 12699257, DOI: 10.1016/s0889-8545(02)00052-9.Peer-Reviewed Original ResearchConceptsEndometrial tissueLocal aromatase activityViable endometrial tissueCases of endometriosisPathogenesis of endometriosisCommon gynecologic disorderRetrograde menstruation theoryRetrograde menstruationGynecologic disordersUterine cavityFallopian tubeEndometrial cellsPeritoneal surfaceAromatase activityPelvic organsPeritoneal cavityLow prevalenceTIMP expressionEndometriosisMenstruationTissueAdditional factorsPathogenesisPrevalenceDiseaseEndometriosis: Interaction of Immune and Endocrine Systems
Seli E, Arici A. Endometriosis: Interaction of Immune and Endocrine Systems. Seminars In Reproductive Medicine 2003, 21: 135-144. PMID: 12917783, DOI: 10.1055/s-2003-41320.Peer-Reviewed Original ResearchConceptsEndometriotic implantsRetrograde menstruationNatural killer cell activityGonadotropin-releasing hormone agonistKiller cell activityObserved clinical improvementCases of endometriosisHumoral immune responseDevelopment of endometriosisCommon gynecologic disorderEndometriosis implantsPelvic painClinical improvementGnRH agonistImmunologic alterationsHormone agonistEndometrial tissueGynecologic disordersHumoral immunityImmunomodulatory effectsUterine cavityImmune cellsMenstrual debrisPeritoneal fluidEndometrial cells
1998
Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells.
Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction 1998, 13: 3492-3495. PMID: 9886538, DOI: 10.1093/humrep/13.12.3492.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell DivisionEndometriosisEndometriumFemaleFollicular FluidGrowth SubstancesHumansMiddle AgedStromal CellsConceptsEndometrial stromal cellsFollicular fluidPeritoneal fluidEndometrial cellsCell proliferationStromal cellsEndometrial stromal cell culturesFollicular fluid contentEndometrial cell proliferationOocyte retrievalStromal cell culturesPeritoneal environmentCell proliferation assaysEndometriosisGrowth-promoting factorsGrowth-promoting effectProliferation assaysWomenMaximum cell proliferationProliferationCellsCell culturesHigher cell proliferationFluid contentThe role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation.
Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Human Reproduction 1998, 13: 1194-1199. PMID: 9647546, DOI: 10.1093/humrep/13.5.1194.Peer-Reviewed Original ResearchConceptsMCP-1 levelsChemotactic protein-1Enzyme-linked immunosorbent assayIntraperitoneal adhesion formationIntraperitoneal adhesionsPg/Monocyte chemotactic protein-1MCP-1 mRNA expressionNormal fertile womenBilateral tubal ligationProtein 1MCP-1 proteinAdhesion formationGroup of womenWound repair modelPelvic adhesionsFertile womenMononuclear cellsPeritoneal injuryMCP-1Tubal ligationReproductive ageEndometriosisBiopsy samplesPatients
1996
Growth-regulated alpha expression in the peritoneal environment with endometriosis.
Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A. Growth-regulated alpha expression in the peritoneal environment with endometriosis. Obstetrics And Gynecology 1996, 88: 1050-6. PMID: 8942852, DOI: 10.1016/s0029-7844(96)00361-4.Peer-Reviewed Original ResearchConceptsAlpha messenger RNAPeritoneal fluid samplesPeritoneal fluidPg/Severe endometriosisFertile womenSevere endometriosis groupNormal fertile womenNeutrophil chemotactic activityReproductive-age womenEndometrial stromal cellsPathogenesis of endometriosisFluid samplesInterleukin-1 alphaMessenger RNAInterleukin-8 receptorEnzyme-linked immunosorbentMann-Whitney testUntreated endometriosisEndometrial biopsyTime-dependent mannerEndometrial diseaseEndometriosis groupEndometrial tissuePeritoneal environment