2021
B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population
Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertility And Sterility 2021, 117: 351-358. PMID: 34809978, DOI: 10.1016/j.fertnstert.2021.09.036.Peer-Reviewed Original ResearchConceptsB-cell lymphoma 6 (Bcl6) expressionLive birth groupLive birthsFertilization populationNormal respondersBirth groupProportion of patientsLive birth ratePopulation of patientsEuploid embryo transferCase-control studyEndometrial tissue samplesPreimplantation genetic testingGroup of womenIVF stimulationMean HSCOREIVF outcomesInfertility centerIVF successMAIN OUTCOMEGroup 2Group 1Embryo transferPatientsClinical decisionA review of the pathophysiology of recurrent implantation failure
Franasiak JM, Alecsandru D, Forman EJ, Gemmell LC, Goldberg JM, Llarena N, Margolis C, Laven J, Schoenmakers S, Seli E. A review of the pathophysiology of recurrent implantation failure. Fertility And Sterility 2021, 116: 1436-1448. PMID: 34674825, DOI: 10.1016/j.fertnstert.2021.09.014.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureImplantation failureMaternal immune systemReproductive tract microbiomeLack of implantationEndometrial synchronyHematologic factorsAnatomic factorsEndocrine milieuReceptive endometriumMaternal interfaceEmbryo transferImmune systemApparent treatmentCompetent blastocystClinical phenomenaHuman reproductionPotential causesImplantationFailureReviewCross talkEndometriumPatientsFactors
2019
The association between assisted reproductive technologies and low birth weight.
Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Current Opinion In Obstetrics & Gynecology 2019, 31: 183-187. PMID: 30893135, DOI: 10.1097/gco.0000000000000535.Peer-Reviewed Original ResearchConceptsLow birth weightFresh embryo transferFrozen embryo transferBirth weightNumber of embryosEmbryo transferReproductive technologiesART-conceived pregnanciesComparable birth weightMain risk factorsEndometrial preparationPerinatal outcomesMultiple gestationsRisk factorsAssisted reproductionPrematurityNewbornsIncidenceRecent studiesPregnancyGestationWeight
2014
mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium
Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsTNF-α expressionTIA-1 expressionEndometrial stromal cellsIL-6Pathogenesis of endometriosisMenstrual cycleTIA-1Endometrial tissueEctopic endometriumImmune factorsHistological scoresCultured human endometrial stromal cellsSteroid hormonesStromal cellsGrowth factorElevated IL-6Ectopic endometrial tissueNormal menstrual cycleEutopic endometrial tissuesGrowth factor expressionT-cell intracellular antigenEndometrial cytokinesEndometrial functionControl women
2011
The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium
Karipcin FS, Ensari TA, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium. Reproductive Sciences 2011, 18: 145-155. PMID: 20889954, PMCID: PMC3343139, DOI: 10.1177/1933719110382307.Peer-Reviewed Original ResearchConceptsEctopic endometriumMenstrual cycleSecretory phaseCytokine expressionHuR expressionNormal endometriumCultured endometrial stromal cellsStromal cellsEctopic endometrial cellsEctopic human endometriumMid-menstrual phaseElevated cytokine levelsEndometrial stromal cellsLate secretory phasePathogenesis of endometriosisCultured stromal cellsTumor necrosis factorMessenger RNACytokine levelsEndometrial cellsEutopic endometriumHuman endometriumNecrosis factorEndometriumEndometriosis
2006
Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx
Daftary GS, Kayisli U, Seli E, Bukulmez O, Arici A, Taylor HS. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. Fertility And Sterility 2006, 87: 367-372. PMID: 17173899, DOI: 10.1016/j.fertnstert.2006.06.041.Peer-Reviewed Original ResearchConceptsEndometrial HOXA10 expressionImplantation rateHOXA10 expressionInfertile womenFertile controlsHOXA10 mRNAPolymerase chain reaction findingsProspective clinical trialsReal-time reverse transcription-polymerase chain reactionReverse transcription-polymerase chain reactionHOXA10 protein expressionExpression of HOXA10Academic medical centerHOXA10 mRNA expressionGlandular epithelial cellsHomeobox gene HOXA10Potential molecular mechanismsBilateral hydrosalpinxHydrosalpinx fluidEndometrial stromaMidluteal phasePolymerase chain reactionClinical trialsSalpingectomyMedical Center
2005
Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window
Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Human Reproduction 2005, 20: 3012-3017. PMID: 16024536, DOI: 10.1093/humrep/dei188.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorInfertile womenLIF expressionFertile controlsExpression of LIFLeukemia inhibitory factor expressionAdverse effectsEndometrial LIF expressionPresence of hydrosalpingesWindow of implantationIVF-embryo transferGlandular epithelial cellsWestern blot findingsLIF immunoreactivityLIF levelsEndometrial receptivityEndometrial expressionImplantation windowPregnancy rateHydrosalpingesSalpingectomyImmunohistochemical analysisLow implantationInhibitory factorFactor expression
1998
Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells.
Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction 1998, 13: 3492-3495. PMID: 9886538, DOI: 10.1093/humrep/13.12.3492.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsFollicular fluidPeritoneal fluidEndometrial cellsCell proliferationStromal cellsEndometrial stromal cell culturesFollicular fluid contentEndometrial cell proliferationOocyte retrievalStromal cell culturesPeritoneal environmentCell proliferation assaysEndometriosisGrowth-promoting factorsGrowth-promoting effectProliferation assaysWomenMaximum cell proliferationProliferationCellsCell culturesHigher cell proliferationFluid content
1996
Growth-regulated alpha expression in the peritoneal environment with endometriosis.
Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A. Growth-regulated alpha expression in the peritoneal environment with endometriosis. Obstetrics And Gynecology 1996, 88: 1050-6. PMID: 8942852, DOI: 10.1016/s0029-7844(96)00361-4.Peer-Reviewed Original ResearchConceptsAlpha messenger RNAPeritoneal fluid samplesPeritoneal fluidPg/Severe endometriosisFertile womenSevere endometriosis groupNormal fertile womenNeutrophil chemotactic activityReproductive-age womenEndometrial stromal cellsPathogenesis of endometriosisFluid samplesInterleukin-1 alphaMessenger RNAInterleukin-8 receptorEnzyme-linked immunosorbentMann-Whitney testUntreated endometriosisEndometrial biopsyTime-dependent mannerEndometrial diseaseEndometriosis groupEndometrial tissuePeritoneal environment