2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescence
2013
Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary
Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) Expression and Activity in the Female Mouse Ovary. Endocrinology 2013, 154: 3877-3887. PMID: 23913446, PMCID: PMC3776864, DOI: 10.1210/en.2013-1341.Peer-Reviewed Original ResearchConceptsGranulosa/cumulus cellsGranulosa cellsMouse ovariesReceptor expressionPrimary mouse granulosa cellsCumulus cellsPregnant mare serum gonadotropinIntracellular cAMPHormone receptor expressionGnRH receptor expressionCultured granulosa cellsOvarian granulosa cellsMouse granulosa cellsMechanism of actionGonadotoxic chemotherapyQuantitative RT-PCRGnRH agonistGnRHR mRNAFertility preservationMouse pituitary cellsLuciferase reporter plasmidSerum gonadotropinPituitary cell linePituitary cellsPituitary tissue
2006
Estradiol Increases Apoptosis in Human Coronary Artery Endothelial Cells by Up-Regulating Fas and Fas Ligand Expression
Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. Estradiol Increases Apoptosis in Human Coronary Artery Endothelial Cells by Up-Regulating Fas and Fas Ligand Expression. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4995-5001. PMID: 17003091, DOI: 10.1210/jc.2006-1225.Peer-Reviewed Original ResearchConceptsHuman coronary artery endothelial cellsCultured human coronary artery endothelial cellsHormone replacement therapyCoronary artery endothelial cellsArtery endothelial cellsReplacement therapyE2 treatmentPlaque stabilityPostmenopausal hormone replacement therapyEndothelial cellsFas/FasL pathwayEffects of E2Effects of estrogenAtherosclerotic plaque formationSignificant concentration-dependent increaseConcentration-dependent increaseFas ligand expressionCardiovascular eventsCardioprotective effectsInhibits atherogenesisMAIN OUTCOMEAnimal modelsFasL pathwayUp-regulating FasLigand expression
2002
Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells
Seli E, Pehlivan T, Selam B, Garcia-Velasco JA, Arici A. Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells. Fertility And Sterility 2002, 77: 542-547. PMID: 11872210, DOI: 10.1016/s0015-0282(01)03223-x.Peer-Reviewed Original ResearchConceptsHuman coronary artery endothelial cellsCoronary artery endothelial cellsMCP-1 expressionHuman umbilical vein endothelial cellsEnzyme-linked immunosorbent assayArtery endothelial cellsMCP-1 mRNAUmbilical vein endothelial cellsEndothelial cellsVein endothelial cellsMCP-1Prospective comparative studyConcentrations of estradiolMCP-1 productionMCP-1 proteinDose-dependent inhibitionVascular endothelial cellsEstrogen treatmentMacrophage recruitmentMAIN OUTCOMEMRNA expressionRibonucleic acidImmunosorbent assayProtein expressionTamoxifen
1997
Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells.
Arici A, Oral E, Bahtiyar O, Engin O, Seli E, Jones EE. Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Human Reproduction 1997, 12: 1233-1239. PMID: 9222008, DOI: 10.1093/humrep/12.6.1233.Peer-Reviewed Original ResearchConceptsFollicular fluid samplesLeukemia inhibitory factorLIF mRNAOvarian stromal cellsGranulosa-lutein cellsFollicular phaseFollicular fluidFluid samplesExpression of LIFPg/Embryo qualityStromal cellsFollicular fluid oestradiol concentrationsLeukemia inhibitory factor expressionTumor necrosis factor alphaPhysiology of ovulationNecrosis factor alphaConcentrations of LIFHuman follicular fluidConcentration-dependent mannerLIF levelsOvarian stimulationStromal cell culturesOvarian functionOestradiol concentrations