2019
Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis
Sofiyeva N, Siepmann T, Barlinn K, Seli E, Ata B. Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis. Reproductive Sciences 2019, 26: 939-953. PMID: 30270741, DOI: 10.1177/1933719118799203.Peer-Reviewed Original ResearchConceptsGonadotropin-releasing hormone analogueSystematic reviewGonadotoxic chemotherapyHormone analogueRisk ratioGnRH agonist-treated patientsGonadotropin-Releasing Hormone AnalogLow-quality evidenceReproductive-aged womenConfidence intervalsSignificant protective effectGonadoprotective effectPresent systematic reviewGnRHa cotreatmentGonadal protectionSupradiaphragmatic radiotherapyCohort studyTrials RegistryGnRHa administrationMenstrual resumptionAutoimmune diseasesSubgroup analysisBreast cancerProtective effectHematological malignancies
2018
Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance
Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAneuploidyBlastomeresDatabases, FactualEmbryo Culture TechniquesEmbryo TransferFemaleFertility Agents, FemaleFertilization in VitroHumansInfertility, FemaleLive BirthOvarian ReserveOvaryOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeConceptsPoor oocyte qualityOvarian reserveLive birth rateDiminished ovarian reserveOocyte yieldOocyte qualityBlastulation rateAMH levelsPoor respondersPoor responseFollicular depletionBirth rateEmbryo transferAneuploidy rateLower live birth ratesYoung womenSTUDY FUNDING/COMPETINGGood prognosis patientsOvarian reserve parametersOvarian reserve testingYoung poor respondersPoor ovarian responseRetrospective cohort studyLower oocyte yieldInterquartile range
2015
Strategies for Controlled Ovarian Stimulation in the Setting of Ovarian Aging
Ata B, Seli E. Strategies for Controlled Ovarian Stimulation in the Setting of Ovarian Aging. Seminars In Reproductive Medicine 2015, 33: 436-448. PMID: 26562286, DOI: 10.1055/s-0035-1567818.Peer-Reviewed Original ResearchConceptsControlled ovarian stimulationOvarian agingOvarian stimulationPossible side effects profileShort GnRH agonist protocolGonadotropin-releasing hormone antagonistGnRH agonist protocolTotal gonadotropin consumptionIU/daySide effect profileCost of medicationsGrowth hormone supplementationHigh-quality evidenceTransdermal testosterone administrationDuration of stimulationQuality of oocytesAppropriate first choiceAgonist protocolCOS protocolsEstradiol primingGonadotropin consumptionGonadotropin dosageEffect profileHormone antagonistHormone supplementation
2005
Fertility preservation options for female patients with malignancies
Seli E, Tangir J. Fertility preservation options for female patients with malignancies. Current Opinion In Obstetrics & Gynecology 2005, 17: 299-308. PMID: 15870565, DOI: 10.1097/01.gco.0000169108.15623.34.Peer-Reviewed Original ResearchConceptsFemale patientsFertility preservationOocyte cryopreservationOvarian tissueGonadotropin-releasing hormone agonistRadical vaginal trachelectomyInitiation of chemotherapyFertility preservation optionsOvarian stimulation protocolsPreservation of fertilityCryopreserved ovarian tissueFirst embryo transferEmbryo cryopreservationImportant health issueVaginal trachelectomyConservative surgeryGynecologic malignanciesEndometrial cancerOvarian cryopreservationHormone agonistCervical cancerFirst pregnancyProgestin treatmentOvarian tumorsOrthotopic transplantation
2002
Optimizing ovulation induction in women with polycystic ovary syndrome
Seli E, Duleba AJ. Optimizing ovulation induction in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2002, 14: 245-254. PMID: 12032379, DOI: 10.1097/00001703-200206000-00002.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicClomipheneFemaleFertility Agents, FemaleHumansMetforminOvulation InductionPolycystic Ovary SyndromePregnancyConceptsPolycystic ovary syndromeOvary syndromeInsulin resistanceOvulation inductionSerum insulinOvulatory functionType 2 diabetes mellitusElevated serum insulinLaparoscopic ovarian drillingPartial ovarian resectionSignificant insulin resistanceCardiovascular risk factorsInsulin-sensitizing agentsNew therapeutic approachesOvarian drillingOvarian resectionClomiphene citrateMetformin useCompensatory hyperinsulinemiaDiabetes mellitusInsulin sensitivityRisk factorsAndrogen levelsTherapeutic approachesTraditional therapies