2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescence
2016
Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship
Babayev E, Lalioti MD, Favero F, Seli E. Cross-Talk Between FSH and Endoplasmic Reticulum Stress: A Mutually Suppressive Relationship. Reproductive Sciences 2016, 23: 352-364. PMID: 26342052, PMCID: PMC5933091, DOI: 10.1177/1933719115602770.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndoplasmic Reticulum StressFemaleFollicle Stimulating HormoneHorsesMiceMice, Inbred C57BLOvaryOvulation InductionPregnancySignal TransductionConceptsFollicle stimulating hormonePregnant mare serum gonadotropinMouse granulosa cellsGranulosa cellsFSH responseSerum gonadotropinFSH stimulationER stressStress-induced cellsPrimary mouse granulosa cellsUntreated granulosa cellsMessenger RNA levelsCalcium adenosine triphosphataseEndoplasmic reticulum stressEstradiol levelsMice 24Estradiol productionIntraperitoneal injectionStimulating hormoneAromatase expressionTP treatmentReticulum stressRNA levelsER stress-associated genesProtein levels
2014
Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH
Karakaya C, Guzeloglu-Kayisli O, Hobbs RJ, Gerasimova T, Uyar A, Erdem M, Oktem M, Erdem A, Gumuslu S, Ercan D, Sakkas D, Comizzoli P, Seli E, Lalioti MD. Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH. Molecular Human Reproduction 2014, 20: 630-643. PMID: 24670307, PMCID: PMC4072182, DOI: 10.1093/molehr/gau024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAnimalsCatsCumulus CellsExonsFemaleFollicle Stimulating HormoneHEK293 CellsHumansInfertility, FemaleOvaryOvulation InductionReceptors, FSHRetrospective StudiesConceptsAlternative splicingAlternative skippingExon 2Species-specific regulationDNA sequence variationPost-transcriptional modificationsFull-length proteinNorth American originMammalian ovarian functionAmino acid substitutionsDifferent genetic backgroundsHormone receptor geneGood comparative modelResult of evolutionSequence variationFollicle-stimulating hormoneSplicing variantsSplicingSpecies-specific formsAcid substitutionsHEK293 cellsFollicle-stimulating hormone receptor (FSHR) geneGenetic backgroundHuman FSHRAmerican origin
2010
Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH
Gerasimova T, Thanasoula MN, Zattas D, Seli E, Sakkas D, Lalioti MD. Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 529-536. PMID: 20061434, PMCID: PMC2840851, DOI: 10.1210/jc.2009-1304.Peer-Reviewed Original ResearchConceptsOvarian responseFSH receptorFSHR mRNAAbnormal ovarian responseOvarian stimulation protocolsForms of infertilityOocytes of womenExtracellular ligand-binding portionHormone receptor variantsOvarian hyperstimulationOvarian stimulationFSHR variantsPoor responseInfertility treatmentT cellsStimulation protocolFollicle growthFSHFertility clinicsCAMP activationCumulus cellsReceptor variantsGenetic causeRT-PCRWomen