2017
Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte–somatic communication†
Lowther KM, Favero F, Yang CR, Taylor HS, Seli E. Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte–somatic communication†. Biology Of Reproduction 2017, 96: 341-351. PMID: 28203794, DOI: 10.1095/biolreprod.116.141234.Peer-Reviewed Original Research
2014
Epab is dispensable for mouse spermatogenesis and male fertility
Ozturk S, Guzeloglu-Kayisli O, Lowther KM, Lalioti MD, Sakkas D, Seli E. Epab is dispensable for mouse spermatogenesis and male fertility. Molecular Reproduction And Development 2014, 81: 390-390. PMID: 24599567, PMCID: PMC4079073, DOI: 10.1002/mrd.22319.Peer-Reviewed Original ResearchAnimalsFertilityGene Expression RegulationMaleMiceMice, KnockoutPoly(A)-Binding ProteinsSeminiferous TubulesSpermatogenesis
2013
mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells
Zhang H, Taylor WR, Joseph G, Caracciolo V, Gonzales DM, Sidell N, Seli E, Blackshear PJ, Kallen CB. mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells. Arteriosclerosis Thrombosis And Vascular Biology 2013, 33: 1212-1220. PMID: 23559629, PMCID: PMC3844532, DOI: 10.1161/atvbaha.113.301496.Peer-Reviewed Original ResearchConceptsVascular endothelial cellsEndothelial cellsAortic endothelial cellsAtherosclerotic lesionsFoam cellsAnti-inflammatory effectsHuman aortic endothelial cellsNuclear factor-κB transcriptional activationLow-density lipoproteinMacrophage foam cellsZinc finger protein 36Vascular inflammationAngiotensin IIInflammatory cytokinesCytokine mRNAZFP36 expressionBacterial lipopolysaccharideHealthy aortaInflammationTarget cellsLesionsZFP36Protein 36CellsMRNA transcripts
2012
Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice
Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, Sasson I, Ilbay O, Sakkas D, Lowther KM, Mehlmann LM, Seli E. Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochemical Journal 2012, 446: 47-58. PMID: 22621333, PMCID: PMC3955213, DOI: 10.1042/bj20120467.Peer-Reviewed Original ResearchConceptsTranslational activationOocyte maturationZygotic genome activationFemale fertilityGenome activationGerminal vesicle stage oocytesDazl mRNAEarly embryogenesisMaternal mRNAsDownstream regulatorsMammalian reproductionGene expressionEPABStage oocytesXenopus oocytesEpidermal growthLate antral folliclesOogenesisMRNAOocytesMaturationProteinFemale miceCumulus expansionAntral folliclesThe mRNA‐Binding Protein Zfp36 Is Upregulated by β‐Adrenergic Stimulation and Represses IL‐6 Production in 3T3‐L1 Adipocytes
Brahma PK, Zhang H, Murray BS, Shu F, Sidell N, Seli E, Kallen CB. The mRNA‐Binding Protein Zfp36 Is Upregulated by β‐Adrenergic Stimulation and Represses IL‐6 Production in 3T3‐L1 Adipocytes. Obesity 2012, 20: 40-47. PMID: 21818148, PMCID: PMC4127993, DOI: 10.1038/oby.2011.259.Peer-Reviewed Original ResearchConceptsAU-rich elementsZFP36 expressionCell type-specific modulatorsPost-transcriptional levelMRNA-binding proteinRetinoic acidZinc finger protein 36Novel mechanistic approachTarget mRNAsMRNA targetsSuch proteinsPotent repressorAdipocyte-derived IL-6Protein 36Chronic inflammatory stateSystemic immune responsesDevelopment of diabetesDependent pathwayDiverse inflammatory disordersZFP36IL-6 productionAdrenergic receptor agonist isoproterenolCyclic adenosine monophosphateInterleukin-6 expressionΒ-Adrenergic Stimulation
2011
The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium
Karipcin FS, Ensari TA, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-Binding Protein HuR is Regulated in the Menstrual Cycle and Repressed in Ectopic Endometrium. Reproductive Sciences 2011, 18: 145-155. PMID: 20889954, PMCID: PMC3343139, DOI: 10.1177/1933719110382307.Peer-Reviewed Original ResearchConceptsEctopic endometriumMenstrual cycleSecretory phaseCytokine expressionHuR expressionNormal endometriumCultured endometrial stromal cellsStromal cellsEctopic endometrial cellsEctopic human endometriumMid-menstrual phaseElevated cytokine levelsEndometrial stromal cellsLate secretory phasePathogenesis of endometriosisCultured stromal cellsTumor necrosis factorMessenger RNACytokine levelsEndometrial cellsEutopic endometriumHuman endometriumNecrosis factorEndometriumEndometriosis
2006
Estradiol Increases Apoptosis in Human Coronary Artery Endothelial Cells by Up-Regulating Fas and Fas Ligand Expression
Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. Estradiol Increases Apoptosis in Human Coronary Artery Endothelial Cells by Up-Regulating Fas and Fas Ligand Expression. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4995-5001. PMID: 17003091, DOI: 10.1210/jc.2006-1225.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCell ProliferationCells, CulturedCoronary VesselsEndothelium, VascularEstradiolFas Ligand ProteinFas ReceptorFemaleGene Expression RegulationHumansMiddle AgedConceptsHuman coronary artery endothelial cellsCultured human coronary artery endothelial cellsHormone replacement therapyCoronary artery endothelial cellsArtery endothelial cellsReplacement therapyE2 treatmentPlaque stabilityPostmenopausal hormone replacement therapyEndothelial cellsFas/FasL pathwayEffects of E2Effects of estrogenAtherosclerotic plaque formationSignificant concentration-dependent increaseConcentration-dependent increaseFas ligand expressionCardiovascular eventsCardioprotective effectsInhibits atherogenesisMAIN OUTCOMEAnimal modelsFasL pathwayUp-regulating FasLigand expression
2002
Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells
Seli E, Pehlivan T, Selam B, Garcia-Velasco JA, Arici A. Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells. Fertility And Sterility 2002, 77: 542-547. PMID: 11872210, DOI: 10.1016/s0015-0282(01)03223-x.Peer-Reviewed Original ResearchConceptsHuman coronary artery endothelial cellsCoronary artery endothelial cellsMCP-1 expressionHuman umbilical vein endothelial cellsEnzyme-linked immunosorbent assayArtery endothelial cellsMCP-1 mRNAUmbilical vein endothelial cellsEndothelial cellsVein endothelial cellsMCP-1Prospective comparative studyConcentrations of estradiolMCP-1 productionMCP-1 proteinDose-dependent inhibitionVascular endothelial cellsEstrogen treatmentMacrophage recruitmentMAIN OUTCOMEMRNA expressionRibonucleic acidImmunosorbent assayProtein expressionTamoxifen
1996
Growth-regulated alpha expression in the peritoneal environment with endometriosis.
Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A. Growth-regulated alpha expression in the peritoneal environment with endometriosis. Obstetrics And Gynecology 1996, 88: 1050-6. PMID: 8942852, DOI: 10.1016/s0029-7844(96)00361-4.Peer-Reviewed Original ResearchConceptsAlpha messenger RNAPeritoneal fluid samplesPeritoneal fluidPg/Severe endometriosisFertile womenSevere endometriosis groupNormal fertile womenNeutrophil chemotactic activityReproductive-age womenEndometrial stromal cellsPathogenesis of endometriosisFluid samplesInterleukin-1 alphaMessenger RNAInterleukin-8 receptorEnzyme-linked immunosorbentMann-Whitney testUntreated endometriosisEndometrial biopsyTime-dependent mannerEndometrial diseaseEndometriosis groupEndometrial tissuePeritoneal environment