2004
Treatment of PCOS with metformin and other insulin-sensitizing agents
Seli E, Duleba AJ. Treatment of PCOS with metformin and other insulin-sensitizing agents. Current Diabetes Reports 2004, 4: 69-75. PMID: 14764283, DOI: 10.1007/s11892-004-0014-8.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansHypoglycemic AgentsInositol PhosphatesMetforminPolycystic Ovary SyndromePolysaccharidesThiazolidinedionesConceptsPolycystic ovary syndromeInsulin-sensitizing agentsSerum insulinInsulin resistanceTreatment of PCOSType 2 diabetes mellitusElevated serum insulinUse of metforminTreatment of womenOvary syndromeCompensatory hyperinsulinemiaDiabetes mellitusOvulatory functionD-chiro-inositolAndrogen levelsCardiovascular disordersMetforminHyperinsulinemiaWomenSignificant proportionTreatmentInsulinAgentsHyperandrogenismAnovulation
2002
Should patients with polycystic ovarian syndrome be treated with metformin?
Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Human Reproduction 2002, 17: 2230-2236. PMID: 12202407, DOI: 10.1093/humrep/17.9.2230.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeTreatment of PCOSInsulin-lowering agentsOvarian syndromePathogenesis of PCOSType 2 diabetes mellitusPromising therapeutic profileEarly spontaneous miscarriageOral antihyperglycaemic agentsInsulin-sensitizing drugsType 2 diabetesRisk of developmentImportant aetiologic factorPlasminogen activator inhibitorSerum lipidsDiabetes mellitusCardioprotective effectsAetiologic factorsAntihyperglycaemic agentsInsulin resistanceSpontaneous miscarriageMetforminTherapeutic profileActivator inhibitorTreatment