2024
Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles
Gill P, Puchalt N, Molinaro T, Werner M, Seli E, Hotaling J, Cheng P. Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles. Journal Of Assisted Reproduction And Genetics 2024, 41: 1213-1219. PMID: 38642270, PMCID: PMC11143111, DOI: 10.1007/s10815-024-03085-x.Peer-Reviewed Original ResearchConceptsLive birth rateIntracytoplasmic sperm injectionClinical pregnancy rateSustained implantation ratesIn vitro fertilizationIn vitro fertilization cyclesPreimplantation genetic testingBlastulation ratePGT-AAneuploidy rateEmbryological outcomesSperm injectionGenetic testingEuploid embryo transferPrevalence of leukocytospermiaRetrospective cohort studyMale partner ageImplantation rateBaseline characteristicsEmbryo transferLeukocytospermiaFertilization cyclesCohort studyPregnancy ratePrimary outcome
2020
The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women
Kim J, Juneau C, Patounakis G, Morin S, Neal S, Seli E, Scott R. The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women. Journal Of Assisted Reproduction And Genetics 2020, 37: 2733-2742. PMID: 32827101, PMCID: PMC7642175, DOI: 10.1007/s10815-020-01930-3.Peer-Reviewed Original ResearchConceptsBody mass indexLower serum AMHLower serum FSHOvarian reserve parametersPresence of PCOSControlled ovarian hyperstimulationNormal-weight counterpartsMature oocytesPercent body fatBF categoriesOvarian hyperstimulationSerum AMHOvarian reservePCOS diagnosisSerum FSHIVF outcomesLess muscle massOvarian responseMass indexFemale obesityInfertility treatmentReserve parametersBody fatInfertile menObesity
2018
How new technical knowledge impacts clinical approach to infertile patients
García-Velasco JA, Seli E. How new technical knowledge impacts clinical approach to infertile patients. Current Opinion In Obstetrics & Gynecology 2018, 30: 137-138. PMID: 29652726, DOI: 10.1097/gco.0000000000000461.Peer-Reviewed Original ResearchAssisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications
Morin SJ, Seli E. Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications. Seminars In Reproductive Medicine 2018, 36: 195-203. PMID: 30866006, DOI: 10.1055/s-0038-1677048.Peer-Reviewed Original ResearchConceptsSevere male factor infertilityART-exposed childrenLow birth weightMale factor infertilityReproductive technologiesSevere monogenic disordersAssisted Reproductive TechnologyMultiple gestationsSubfertile womenFactor infertilityMetabolic derangementsPremature birthAbsolute riskBirth weightCardiovascular diseaseAdditional diagnosisNumber of womenClinical realityMultiple studiesMonogenic disordersNumber of couplesRiskOrigin of diseaseDiseaseWomen
2011
The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis
Schober CS, Aydiner F, Booth CJ, Seli E, Reinke V. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Cells And Development 2011, 128: 178-190. PMID: 21277975, DOI: 10.1016/j.mod.2011.01.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChromosomes, MammalianFemaleHistonesInfertility, FemaleInfertility, MaleMaleMeiosisMiceMice, Inbred C57BLMice, Mutant StrainsMutagenesis, InsertionalOocytesOogenesisOrgan SizeOrgan SpecificityOvaryPhenotypePhosphorylationProtein Serine-Threonine KinasesSeminiferous EpitheliumSpermatogenesisTestisTumor Suppressor Protein p53ConceptsMeiotic progressionNormal meiotic progressionGene trap insertionConserved roleDrosophila oogenesisMammalian gametogenesisMammalian oogenesisVRK1 activityPhosphorylation substratesFemale meiosisInvertebrate speciesProliferation defectMale spermatogoniaChromosomal configurationsMetaphase plateVRK1OogenesisVRK1 expressionFailure of oocytesMouse strainsDrosophilaMeiosisGametogenesisChromosomesLoci
2005
Spermatozoal nuclear determinants of reproductive outcome: implications for ART
Seli E, Sakkas D. Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Human Reproduction Update 2005, 11: 337-349. PMID: 15863434, DOI: 10.1093/humupd/dmi011.Peer-Reviewed Original ResearchMeSH KeywordsChromosomes, Human, YFertilization in VitroHumansInfertility, MaleMaleSex Chromosome AberrationsSpermatozoaConceptsPaternal genomeEpigenetic regulationChromosome contentDNA strand breaksNuclear determinantsStrand breaksGenomeImportant functionsNuclear factorRecent findingsSpecific mechanismsReproductive outcomesExact mechanismNumerical abnormalitiesAssisted reproduction technology (ART) outcomesTreatment addressesReproductionMale factor infertilityY chromosome microdeletionsMale fertility potentialRegulationOocytesMechanismChromosome microdeletionsFactor infertility
2003
Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis
Sakkas D, Seli E, Bizzaro D, Tarozzi N, Manicardi GC. Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis. Reproductive BioMedicine Online 2003, 7: 428-432. PMID: 14656403, DOI: 10.1016/s1472-6483(10)61886-x.Peer-Reviewed Original ResearchConceptsNuclear DNA strand breaksDNA strand breaksAbnormal semen parametersAbnormal spermatozoaMale infertilitySemen parametersAbnormal persistenceApoptotic marker proteinsStrand breaksCertain causesHuman spermatozoaMarker proteinsApoptosisNumerous studiesSpermatogenesisSpermatozoaHumansInfertilityAbnormalities