2024
Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles
Gill P, Puchalt N, Molinaro T, Werner M, Seli E, Hotaling J, Cheng P. Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles. Journal Of Assisted Reproduction And Genetics 2024, 41: 1213-1219. PMID: 38642270, PMCID: PMC11143111, DOI: 10.1007/s10815-024-03085-x.Peer-Reviewed Original ResearchConceptsLive birth rateIntracytoplasmic sperm injectionClinical pregnancy rateSustained implantation ratesIn vitro fertilizationIn vitro fertilization cyclesPreimplantation genetic testingBlastulation ratePGT-AAneuploidy rateEmbryological outcomesSperm injectionGenetic testingEuploid embryo transferPrevalence of leukocytospermiaRetrospective cohort studyMale partner ageImplantation rateBaseline characteristicsEmbryo transferLeukocytospermiaFertilization cyclesCohort studyPregnancy ratePrimary outcome
2023
Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging
Garg A, Seli E. Leukocyte telomere length and DNA methylome as biomarkers of ovarian reserve and embryo aneuploidy: the intricate relationship between somatic and reproductive aging. Fertility And Sterility 2023, 121: 26-33. PMID: 37979607, DOI: 10.1016/j.fertnstert.2023.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyBiomarkersEpigenomeFemaleHumansInfertility, FemaleLeukocytesOvarian ReserveTelomereConceptsPoor ovarian responseLeukocyte telomere lengthOvarian reserveTelomere lengthAssisted Reproductive TechnologyOvarian responseFollicular somatic cellsMethylome changesDNA methylomePrevalence of infertilityDiminished ovarian reserveSomatic cellsCellular agingEpigenetic clocksDNA methylation ageReproductive potentialReproductive declineOvarian agingSurrogate biomarkerCommon causeMethylomeART outcomesChronologic ageEmbryo aneuploidyReproductive function
2020
Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization
Hanson BM, Tao X, Zhan Y, Kim JG, Klimczak AM, Herlihy NS, Scott RT, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization. Fertility And Sterility 2020, 115: 957-965. PMID: 33272640, DOI: 10.1016/j.fertnstert.2020.09.164.Peer-Reviewed Original ResearchConceptsWhite blood cellsPatient ageInfertile womenCumulus cellsBlood cellsEmbryonic aneuploidyPeak estradiol levelsAntimüllerian hormone levelsProspective cohort studyTelomere lengthNumber of oocytesShorter telomere lengthReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHigh rateWarrants further investigationTelomere length assessmentSignificant overlap existsCohort studyOocyte retrievalSingle centerEstradiol levelsInfertile populationMaternal agePolymerase chain reactionYoung women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model
Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT, Seli EU. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Human Reproduction 2020, 35: 2579-2588. PMID: 33049778, DOI: 10.1093/humrep/deaa206.Peer-Reviewed Original ResearchConceptsPoor ovarian responseWhite blood cellsPolycystic ovary syndromeOvarian responseOvarian stimulationChronologic ageWBC samplesEpigenetic age accelerationCumulus cellsAge accelerationYoung womenSTUDY FUNDING/COMPETINGBlood cellsProspective cohort studyGood responder groupCommon clinical challengePeripheral blood samplesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of agePatient's chronologic ageGeneral health consequencesCC samplesAge-related changesAge prediction model
2019
Cumulus cells have longer telomeres than leukocytes in reproductive-age women
Lara-Molina EE, Franasiak JM, Marin D, Tao X, Díaz-Gimeno P, Florensa M, Martin M, Seli E, Pellicer A. Cumulus cells have longer telomeres than leukocytes in reproductive-age women. Fertility And Sterility 2019, 113: 217-223. PMID: 31594634, DOI: 10.1016/j.fertnstert.2019.08.089.Peer-Reviewed Original ResearchConceptsLeukocyte telomere lengthGranulosa cellsCumulus cellsTelomere lengthAssisted reproductive technology centerRelative leukocyte telomere lengthProspective noninterventional studyAntimüllerian hormone levelsAntral follicle countReproductive-age womenReproductive technology centerLonger telomeresNoninterventional studyFollicle countMean ageHormone levelsFollicular environmentMAIN OUTCOMEMature folliclesStudy subjectsSignificant associationFollicular cellsMean numberMature oocytesSignificant differences
2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescence