2008
The MHC class I peptide repertoire is molded by the transcriptome
Fortier M, Caron E, Hardy M, Voisin G, Lemieux S, Perreault C, Thibault P. The MHC class I peptide repertoire is molded by the transcriptome. Journal Of Experimental Medicine 2008, 205: 595-610. PMID: 18299400, PMCID: PMC2275383, DOI: 10.1084/jem.20071985.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsCell LineCell Line, TumorComputational BiologyGene Expression ProfilingGenes, MHC Class IHistocompatibility Antigens Class IMiceMultiprotein ComplexesOligonucleotide Array Sequence AnalysisPeptidesProtein BindingRNA, MessengerTandem Mass SpectrometryT-LymphocytesTransfectionConceptsMIP repertoireCyclin/cyclin-dependent kinasePrimary mouse thymocytesCyclin-dependent kinasesMass spectrometry approachMouse thymocytesAbundant transcriptsGlobal profilingHigh-throughput analysisPosttranscriptional mechanismsNeoplastic thymocytesRelative abundanceTranscriptomeMHC class INeoplastic transformationCancer cellsMHC IMolecular compositionPeptidomics dataRepertoirePeptidesClass IMajor histocompatibility complex I moleculesThymocytesHelicases
2007
The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature.
Fortier M, Caron E, Hardy M, Voisin G, Lemieux S, Perreault C, Thibault P. The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature. Blood 2007, 110: 1327. DOI: 10.1182/blood.v110.11.1327.1327.Peer-Reviewed Original ResearchSource mRNATissue-specific signaturesBiological replicatesPrimary mouse thymocytesEL4 cellsNeoplastic transformationRelative quantificationCancer cellsRelative expressionExpression ratioMass spectrometry approachMRNA levelsAbundant transcriptsTranscriptomic dataHigh-throughput analysisMHC IPosttranscriptional mechanismsNeoplastic thymocytesSurvival signalsNormal thymocytesSource proteinsRelative abundanceIntracellular pathogensSpearman correlation coefficientNeoplastic cells