2024
Deciphering the HLA-E immunopeptidome with mass spectrometry: an opportunity for universal mRNA vaccines and T-cell-directed immunotherapies
Weitzen M, Shahbazy M, Kapoor S, Caron E. Deciphering the HLA-E immunopeptidome with mass spectrometry: an opportunity for universal mRNA vaccines and T-cell-directed immunotherapies. Frontiers In Immunology 2024, 15: 1442783. PMID: 39301027, PMCID: PMC11410602, DOI: 10.3389/fimmu.2024.1442783.Peer-Reviewed Original ResearchMass spectrometryHLA-EHLA moleculesT-cell-directed immunotherapyCD8+ T cellsNovel cell surface antigensNon-classical HLA-EHLA-E moleculesCell surface antigensPeptides to CD8T cellsMRNA vaccinesTherapeutic efficacySurface antigensImmunotherapyMoleculesSpectrometryTherapeutic targetImmunopeptidomePathogen-derivedCD8Peptide repertoirePeptide fragmentsHLAMinimal polymorphism
2022
Cellular senescence is immunogenic and promotes anti-tumor immunity
Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, Ruano I, Attolini C, Prats N, López-Domínguez J, Kovatcheva M, Garralda E, Muñoz J, Caron E, Abad M, Gros A, Pietrocola F, Serrano M. Cellular senescence is immunogenic and promotes anti-tumor immunity. Cancer Discovery 2022, 13: 410-431. PMID: 36302218, PMCID: PMC7614152, DOI: 10.1158/2159-8290.cd-22-0523.Peer-Reviewed Original ResearchConceptsCD8 T cellsAntitumor immune responseImmunogenic cell deathDendritic cellsSenescent cancer cellsT cellsCancer cellsImmune responseAntigen-specific CD8 T cellsSenescent cellsRelease of alarminsAnti-tumor immunityInnate immune cellsHuman primary cancer cellsActivation of IFNCellular senescencePrimary cancer cellsAdaptive immune systemCell deathCD8 lymphocytesAntitumor protectionImmune cellsImmune systemContext of cancerInduction of senescence
2018
A tissue-based draft map of the murine MHC class I immunopeptidome
Schuster H, Shao W, Weiss T, Pedrioli P, Roth P, Weller M, Campbell D, Deutsch E, Moritz R, Planz O, Rammensee H, Aebersold R, Caron E. A tissue-based draft map of the murine MHC class I immunopeptidome. Scientific Data 2018, 5: 180157. PMID: 30084848, PMCID: PMC6080492, DOI: 10.1038/sdata.2018.157.Peer-Reviewed Original ResearchConceptsMHC class IClass IMurine MHC class IPotential tumor-associated antigenMajor histocompatibility complex class IHistocompatibility complex class ITumor-associated antigensComplex class IC57BL/6 miceT cellsTranslational immunologyCancer modelImmune systemNormal tissuesMS injectionMost tissuesTissueInitial qualitative dataTotal numberPeptidesCD8AtlasAntigenMice
2006
Asynchronous Differentiation of CD8 T Cells That Recognize Dominant and Cryptic Antigens
Baron C, Meunier M, Caron É, Côté C, Cameron M, Kelvin D, LeBlanc R, Rineau V, Perreault C. Asynchronous Differentiation of CD8 T Cells That Recognize Dominant and Cryptic Antigens. The Journal Of Immunology 2006, 177: 8466-8475. PMID: 17142744, DOI: 10.4049/jimmunol.177.12.8466.Peer-Reviewed Original ResearchConceptsCD8 T cellsT cell responsesT cellsDay 10Cell responsesEffector CD8 T cellsEffector T cellsT cell differentiation markersT cell repertoireT cell differentiation programMouse AgCryptic antigensEffector potentialCell differentiation markersImmune responseCell repertoireEffector functionsAg specificityDay 15Differentiation programSelective expansionDifferentiation markersCell differentiation programLongitudinal analysisContraction phase