2022
Cellular senescence is immunogenic and promotes anti-tumor immunity
Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, Ruano I, Attolini C, Prats N, López-Domínguez J, Kovatcheva M, Garralda E, Muñoz J, Caron E, Abad M, Gros A, Pietrocola F, Serrano M. Cellular senescence is immunogenic and promotes anti-tumor immunity. Cancer Discovery 2022, 13: 410-431. PMID: 36302218, PMCID: PMC7614152, DOI: 10.1158/2159-8290.cd-22-0523.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCellular SenescenceHumansMiceMice, Inbred C57BLNeoplasmsTumor MicroenvironmentConceptsCD8 T cellsAntitumor immune responseImmunogenic cell deathDendritic cellsSenescent cancer cellsT cellsCancer cellsImmune responseAntigen-specific CD8 T cellsSenescent cellsRelease of alarminsAnti-tumor immunityInnate immune cellsHuman primary cancer cellsActivation of IFNCellular senescencePrimary cancer cellsAdaptive immune systemCell deathCD8 lymphocytesAntitumor protectionImmune cellsImmune systemContext of cancerInduction of senescence
2014
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 2014, 515: 577-581. PMID: 25428507, PMCID: PMC4279952, DOI: 10.1038/nature13988.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntigens, NeoplasmCancer VaccinesCD8-Positive T-LymphocytesCell Cycle CheckpointsEpitopesImmunotherapyMaleMiceSarcomaVaccines, Synthetic
2011
The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
Caron E, Vincent K, Fortier M, Laverdure J, Bramoullé A, Hardy M, Voisin G, Roux P, Lemieux S, Thibault P, Perreault C. The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation. Molecular Systems Biology 2011, 7: msb201168. PMID: 21952136, PMCID: PMC3202804, DOI: 10.1038/msb.2011.68.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell Line, TumorCell MembraneGene Expression ProfilingHigh-Throughput Screening AssaysHistocompatibility Antigens Class IImmunityMajor Histocompatibility ComplexMass SpectrometryMetabolic Networks and PathwaysMiceOligonucleotide Array Sequence AnalysisPeptidesProteomicsSignal TransductionSirolimusSystems BiologyTandem Mass SpectrometryTOR Serine-Threonine KinasesConceptsCell surfaceMass spectrometry-based approachSystems-level evidenceSelf/non-self discriminationCellular regulationPredictive biologyCellular metabolic activityCellular metabolismNon-self discriminationRapamycin resultsMammalian targetMHC IBiochemical networksCD8 T lymphocytesSystems immunologyMajor histocompatibility complex (MHC) class I moleculesMetabolic eventsExtrinsic factorsMetabolic activityIntegrative viewClass I moleculesImmunotherapeutic interventionsT lymphocytesEssence of selfSystem-level perspective
2006
Asynchronous Differentiation of CD8 T Cells That Recognize Dominant and Cryptic Antigens
Baron C, Meunier M, Caron É, Côté C, Cameron M, Kelvin D, LeBlanc R, Rineau V, Perreault C. Asynchronous Differentiation of CD8 T Cells That Recognize Dominant and Cryptic Antigens. The Journal Of Immunology 2006, 177: 8466-8475. PMID: 17142744, DOI: 10.4049/jimmunol.177.12.8466.Peer-Reviewed Original ResearchConceptsCD8 T cellsT cell responsesT cellsDay 10Cell responsesEffector CD8 T cellsEffector T cellsT cell differentiation markersT cell repertoireT cell differentiation programMouse AgCryptic antigensEffector potentialCell differentiation markersImmune responseCell repertoireEffector functionsAg specificityDay 15Differentiation programSelective expansionDifferentiation markersCell differentiation programLongitudinal analysisContraction phase
2005
The structure and location of SIMP/STT3B account for its prominent imprint on the MHC I immunopeptidome
Caron É, Charbonneau R, Huppé G, Brochu S, Perreault C. The structure and location of SIMP/STT3B account for its prominent imprint on the MHC I immunopeptidome. International Immunology 2005, 17: 1583-1596. PMID: 16263756, DOI: 10.1093/intimm/dxh336.Peer-Reviewed Original Research