2011
The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
Caron E, Vincent K, Fortier M, Laverdure J, Bramoullé A, Hardy M, Voisin G, Roux P, Lemieux S, Thibault P, Perreault C. The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation. Molecular Systems Biology 2011, 7: msb201168. PMID: 21952136, PMCID: PMC3202804, DOI: 10.1038/msb.2011.68.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell Line, TumorCell MembraneGene Expression ProfilingHigh-Throughput Screening AssaysHistocompatibility Antigens Class IImmunityMajor Histocompatibility ComplexMass SpectrometryMetabolic Networks and PathwaysMiceOligonucleotide Array Sequence AnalysisPeptidesProteomicsSignal TransductionSirolimusSystems BiologyTandem Mass SpectrometryTOR Serine-Threonine KinasesConceptsCell surfaceMass spectrometry-based approachSystems-level evidenceSelf/non-self discriminationCellular regulationPredictive biologyCellular metabolic activityCellular metabolismNon-self discriminationRapamycin resultsMammalian targetMHC IBiochemical networksCD8 T lymphocytesSystems immunologyMajor histocompatibility complex (MHC) class I moleculesMetabolic eventsExtrinsic factorsMetabolic activityIntegrative viewClass I moleculesImmunotherapeutic interventionsT lymphocytesEssence of selfSystem-level perspective
2009
ER stress affects processing of MHC class I-associated peptides
Granados D, Tanguay P, Hardy M, Caron É, de Verteuil D, Meloche S, Perreault C. ER stress affects processing of MHC class I-associated peptides. BMC Immunology 2009, 10: 10. PMID: 19220912, PMCID: PMC2657905, DOI: 10.1186/1471-2172-10-10.Peer-Reviewed Original Research
2008
The MHC class I peptide repertoire is molded by the transcriptome
Fortier M, Caron E, Hardy M, Voisin G, Lemieux S, Perreault C, Thibault P. The MHC class I peptide repertoire is molded by the transcriptome. Journal Of Experimental Medicine 2008, 205: 595-610. PMID: 18299400, PMCID: PMC2275383, DOI: 10.1084/jem.20071985.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsCell LineCell Line, TumorComputational BiologyGene Expression ProfilingGenes, MHC Class IHistocompatibility Antigens Class IMiceMultiprotein ComplexesOligonucleotide Array Sequence AnalysisPeptidesProtein BindingRNA, MessengerTandem Mass SpectrometryT-LymphocytesTransfectionConceptsMIP repertoireCyclin/cyclin-dependent kinasePrimary mouse thymocytesCyclin-dependent kinasesMass spectrometry approachMouse thymocytesAbundant transcriptsGlobal profilingHigh-throughput analysisPosttranscriptional mechanismsNeoplastic thymocytesRelative abundanceTranscriptomeMHC class INeoplastic transformationCancer cellsMHC IMolecular compositionPeptidomics dataRepertoirePeptidesClass IMajor histocompatibility complex I moleculesThymocytesHelicases